Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098323557> ?p ?o ?g. }
- W2098323557 endingPage "464" @default.
- W2098323557 startingPage "455" @default.
- W2098323557 abstract "Synthetic curcuminoid EF24 was studied for its effect on the maturation and inflammatory response in murine bone marrow derived immortalized JAWS II dendritic cells (DCs). EF24 reduced the expression of LPS-induced MHC class II, CD80 and CD86 molecules. It also abrogated the appearance of dendrites, a typical characteristic of mature DCs. These effects were accompanied by the inhibition of LPS-induced activation of transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB). Simultaneous reduction of pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, IL-6] both at the mRNA and secreted levels was also observed. To investigate the dependency of LPS effects on MyD88 adaptor protein, we transfected JAWS II DCs with dominant negative MyD88 plasmid construct (MyD88-DN). EF24 reduced NF-κB activity and TNF-α secretion in a MyD88-dependent manner. These results suggest that EF24 modulates DCs by suppressing their maturation and reducing the secretion of inflammatory cytokines. Further, it appears that EF24 acts at or upstream of MyD88 in the LPS-TLR4/MyD88/NF-κB pathway." @default.
- W2098323557 created "2016-06-24" @default.
- W2098323557 creator A5006430684 @default.
- W2098323557 creator A5018397996 @default.
- W2098323557 creator A5035668092 @default.
- W2098323557 creator A5075766769 @default.
- W2098323557 creator A5091711589 @default.
- W2098323557 date "2012-02-29" @default.
- W2098323557 modified "2023-10-09" @default.
- W2098323557 title "EF24 suppresses maturation and inflammatory response in dendritic cells" @default.
- W2098323557 cites W110788161 @default.
- W2098323557 cites W1504924831 @default.
- W2098323557 cites W1577882287 @default.
- W2098323557 cites W1596764898 @default.
- W2098323557 cites W1964431874 @default.
- W2098323557 cites W1970177550 @default.
- W2098323557 cites W1972041876 @default.
- W2098323557 cites W1975770667 @default.
- W2098323557 cites W1976194786 @default.
- W2098323557 cites W1976300852 @default.
- W2098323557 cites W1977905350 @default.
- W2098323557 cites W1990260730 @default.
- W2098323557 cites W1992024672 @default.
- W2098323557 cites W1997149430 @default.
- W2098323557 cites W1999702104 @default.
- W2098323557 cites W2004827880 @default.
- W2098323557 cites W2009225001 @default.
- W2098323557 cites W2017883909 @default.
- W2098323557 cites W2033877575 @default.
- W2098323557 cites W2048736082 @default.
- W2098323557 cites W2056879548 @default.
- W2098323557 cites W2078009629 @default.
- W2098323557 cites W2083543804 @default.
- W2098323557 cites W2086957326 @default.
- W2098323557 cites W2101430062 @default.
- W2098323557 cites W2134557327 @default.
- W2098323557 cites W2137396961 @default.
- W2098323557 cites W2140040520 @default.
- W2098323557 cites W2149643192 @default.
- W2098323557 cites W2149988172 @default.
- W2098323557 cites W2156234074 @default.
- W2098323557 cites W2160566158 @default.
- W2098323557 cites W2163190055 @default.
- W2098323557 cites W2163646754 @default.
- W2098323557 cites W2166846320 @default.
- W2098323557 cites W2419269917 @default.
- W2098323557 cites W4313331452 @default.
- W2098323557 cites W94773966 @default.
- W2098323557 doi "https://doi.org/10.1093/intimm/dxr121" @default.
- W2098323557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3385421" @default.
- W2098323557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22378503" @default.
- W2098323557 hasPublicationYear "2012" @default.
- W2098323557 type Work @default.
- W2098323557 sameAs 2098323557 @default.
- W2098323557 citedByCount "28" @default.
- W2098323557 countsByYear W20983235572013 @default.
- W2098323557 countsByYear W20983235572014 @default.
- W2098323557 countsByYear W20983235572015 @default.
- W2098323557 countsByYear W20983235572018 @default.
- W2098323557 countsByYear W20983235572019 @default.
- W2098323557 countsByYear W20983235572020 @default.
- W2098323557 countsByYear W20983235572021 @default.
- W2098323557 countsByYear W20983235572022 @default.
- W2098323557 countsByYear W20983235572023 @default.
- W2098323557 crossrefType "journal-article" @default.
- W2098323557 hasAuthorship W2098323557A5006430684 @default.
- W2098323557 hasAuthorship W2098323557A5018397996 @default.
- W2098323557 hasAuthorship W2098323557A5035668092 @default.
- W2098323557 hasAuthorship W2098323557A5075766769 @default.
- W2098323557 hasAuthorship W2098323557A5091711589 @default.
- W2098323557 hasBestOaLocation W20983235571 @default.
- W2098323557 hasConcept C104317684 @default.
- W2098323557 hasConcept C123298856 @default.
- W2098323557 hasConcept C127716648 @default.
- W2098323557 hasConcept C153911025 @default.
- W2098323557 hasConcept C154317977 @default.
- W2098323557 hasConcept C164027704 @default.
- W2098323557 hasConcept C17991360 @default.
- W2098323557 hasConcept C185592680 @default.
- W2098323557 hasConcept C202751555 @default.
- W2098323557 hasConcept C203014093 @default.
- W2098323557 hasConcept C2776070231 @default.
- W2098323557 hasConcept C2776914184 @default.
- W2098323557 hasConcept C2777730290 @default.
- W2098323557 hasConcept C2778170410 @default.
- W2098323557 hasConcept C2778297628 @default.
- W2098323557 hasConcept C2781101188 @default.
- W2098323557 hasConcept C39347974 @default.
- W2098323557 hasConcept C49039625 @default.
- W2098323557 hasConcept C55493867 @default.
- W2098323557 hasConcept C62478195 @default.
- W2098323557 hasConcept C86339819 @default.
- W2098323557 hasConcept C86803240 @default.
- W2098323557 hasConcept C8891405 @default.
- W2098323557 hasConcept C95444343 @default.
- W2098323557 hasConceptScore W2098323557C104317684 @default.
- W2098323557 hasConceptScore W2098323557C123298856 @default.
- W2098323557 hasConceptScore W2098323557C127716648 @default.