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- W2098332335 abstract "For many years the pharmaceutical industry did not pursue the development of antimicrobial agents that specifically targeted Gram-positive bacteria. Semi-synthetic penicillins and vancomycin were the mainstays of therapy for methicillin-susceptible and -resistant strains of staphylococci, respectively, as was penicillin for Streptococcus pneumoniae and beta-lactam-aminoglycoside combinations for serious enterococcal infections. In the 1980s enterococci resistant to glycopeptides emerged, followed shortly thereafter by a dissemination of penicillin-insensitive S. pneumoniae and, more recently, the occurrence of vancomycin-intermediately susceptible Staphylococcus aureus. The emergence of fully glycopeptide-resistant S. aureus is clearly on the horizon. Multi-resistant Gram-positive bacteria now pose an important therapeutic challenge for clinicians. New drugs with activity against some of these dangerous pathogens have recently been pursued, and linezolid, the first member of the oxazolidinone class, has now been licensed for clinical use in many countries. This drug has excellent in vitro and in vivo activity against all clinically relevant multi-resistant Gram-positive cocci and fills an important void in infectious disease chemotherapy." @default.
- W2098332335 created "2016-06-24" @default.
- W2098332335 creator A5066014473 @default.
- W2098332335 creator A5084829703 @default.
- W2098332335 date "2001-04-01" @default.
- W2098332335 modified "2023-10-17" @default.
- W2098332335 title "Oxazolidinones: new players in the battle against multi-resistant Gram-positive bacteria" @default.
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- W2098332335 doi "https://doi.org/10.1517/14728214.6.1.43" @default.
- W2098332335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15989495" @default.
- W2098332335 hasPublicationYear "2001" @default.
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