Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098332825> ?p ?o ?g. }
- W2098332825 endingPage "L558" @default.
- W2098332825 startingPage "L550" @default.
- W2098332825 abstract "Many extremely preterm infants continue to suffer from bronchopulmonary dysplasia, which results from abnormal saccular-stage lung development. Here, we show that fibroblast growth factor-10 (FGF-10) is required for saccular lung development and reduced in the lung tissue of infants with bronchopulmonary dysplasia. Although exposure to bacteria increases the risk of bronchopulmonary dysplasia, no molecular target has been identified connecting inflammatory stimuli and abnormal lung development. In an experimental mouse model of saccular lung development, activation of Toll-like receptor 2 (TLR2) or Toll-like receptor 4 (TLR4) inhibited FGF-10 expression, leading to abnormal saccular airway morphogenesis. In addition, Toll-mediated FGF-10 inhibition disrupted the normal positioning of myofibroblasts around saccular airways, similar to the mislocalization of myofibroblasts seen in patients with bronchopulmonary dysplasia. Reduced FGF-10 expression may therefore link the innate immune system and impaired lung development in bronchopulmonary dysplasia." @default.
- W2098332825 created "2016-06-24" @default.
- W2098332825 creator A5002545908 @default.
- W2098332825 creator A5020568147 @default.
- W2098332825 creator A5023416974 @default.
- W2098332825 creator A5029006151 @default.
- W2098332825 creator A5032192273 @default.
- W2098332825 creator A5033559851 @default.
- W2098332825 date "2007-02-01" @default.
- W2098332825 modified "2023-09-25" @default.
- W2098332825 title "FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation" @default.
- W2098332825 cites W1520629469 @default.
- W2098332825 cites W1575984269 @default.
- W2098332825 cites W1698663755 @default.
- W2098332825 cites W1738317710 @default.
- W2098332825 cites W1963608454 @default.
- W2098332825 cites W1967213726 @default.
- W2098332825 cites W1976275386 @default.
- W2098332825 cites W1982461498 @default.
- W2098332825 cites W1987915373 @default.
- W2098332825 cites W1994566614 @default.
- W2098332825 cites W1995620639 @default.
- W2098332825 cites W1997948433 @default.
- W2098332825 cites W1999194263 @default.
- W2098332825 cites W2007071730 @default.
- W2098332825 cites W2007413389 @default.
- W2098332825 cites W2013084916 @default.
- W2098332825 cites W2016601952 @default.
- W2098332825 cites W2023185970 @default.
- W2098332825 cites W2033988784 @default.
- W2098332825 cites W2036183355 @default.
- W2098332825 cites W2041778400 @default.
- W2098332825 cites W2069646609 @default.
- W2098332825 cites W2078499765 @default.
- W2098332825 cites W2081866939 @default.
- W2098332825 cites W2083398588 @default.
- W2098332825 cites W2104910525 @default.
- W2098332825 cites W2110042849 @default.
- W2098332825 cites W2111549179 @default.
- W2098332825 cites W2113769407 @default.
- W2098332825 cites W2123921311 @default.
- W2098332825 cites W2126361673 @default.
- W2098332825 cites W2130526211 @default.
- W2098332825 cites W2137590150 @default.
- W2098332825 cites W2139041007 @default.
- W2098332825 cites W2139867627 @default.
- W2098332825 cites W2145785767 @default.
- W2098332825 cites W2154294808 @default.
- W2098332825 cites W2159874728 @default.
- W2098332825 cites W2164101293 @default.
- W2098332825 cites W2164652600 @default.
- W2098332825 cites W2165392704 @default.
- W2098332825 cites W219550331 @default.
- W2098332825 doi "https://doi.org/10.1152/ajplung.00329.2006" @default.
- W2098332825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17071719" @default.
- W2098332825 hasPublicationYear "2007" @default.
- W2098332825 type Work @default.
- W2098332825 sameAs 2098332825 @default.
- W2098332825 citedByCount "101" @default.
- W2098332825 countsByYear W20983328252012 @default.
- W2098332825 countsByYear W20983328252013 @default.
- W2098332825 countsByYear W20983328252014 @default.
- W2098332825 countsByYear W20983328252015 @default.
- W2098332825 countsByYear W20983328252016 @default.
- W2098332825 countsByYear W20983328252017 @default.
- W2098332825 countsByYear W20983328252018 @default.
- W2098332825 countsByYear W20983328252019 @default.
- W2098332825 countsByYear W20983328252020 @default.
- W2098332825 countsByYear W20983328252021 @default.
- W2098332825 countsByYear W20983328252022 @default.
- W2098332825 countsByYear W20983328252023 @default.
- W2098332825 crossrefType "journal-article" @default.
- W2098332825 hasAuthorship W2098332825A5002545908 @default.
- W2098332825 hasAuthorship W2098332825A5020568147 @default.
- W2098332825 hasAuthorship W2098332825A5023416974 @default.
- W2098332825 hasAuthorship W2098332825A5029006151 @default.
- W2098332825 hasAuthorship W2098332825A5032192273 @default.
- W2098332825 hasAuthorship W2098332825A5033559851 @default.
- W2098332825 hasConcept C126322002 @default.
- W2098332825 hasConcept C136449434 @default.
- W2098332825 hasConcept C142724271 @default.
- W2098332825 hasConcept C146759223 @default.
- W2098332825 hasConcept C170493617 @default.
- W2098332825 hasConcept C203014093 @default.
- W2098332825 hasConcept C207865475 @default.
- W2098332825 hasConcept C2775894508 @default.
- W2098332825 hasConcept C2776070231 @default.
- W2098332825 hasConcept C2776709828 @default.
- W2098332825 hasConcept C2777714996 @default.
- W2098332825 hasConcept C2778376644 @default.
- W2098332825 hasConcept C2778721537 @default.
- W2098332825 hasConcept C2779234561 @default.
- W2098332825 hasConcept C2780559512 @default.
- W2098332825 hasConcept C54355233 @default.
- W2098332825 hasConcept C71924100 @default.
- W2098332825 hasConcept C74373430 @default.
- W2098332825 hasConcept C86803240 @default.
- W2098332825 hasConcept C8891405 @default.