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- W2098362022 abstract "During 1986-1989, a bacille Calmette-Guérin (BCG) vaccine trial was carried out in northern Malawi. The effects of age, sex, and prevaccination delayed-type hypersensitivity (DTH) on the time course of the DTH response over 1-36 months after vaccination were studied in 2418 persons. DTH response increased rapidly, to peak at 31-90 days after vaccination, when most persons had a measurable response. This was followed by a marked decline by 181-365 days, particularly in those <15 years old at vaccination, followed by a more gradual decline. Prevaccination DTH was the single best predictor of postvaccination DTH. BCG-induced DTH responsiveness appears to decline more rapidly in tropical than in temperate environments. This may reflect high prevalence of exposure to other infections, which induce a Th2 bias or compete for space within the T lymphocyte compartment. The inability of some persons to mount a persistent DTH response probably reflects genetic background and/or environmental exposure history." @default.
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- W2098362022 date "2002-09-15" @default.
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- W2098362022 title "Kinetics of Delayed‐Type Hypersensitivity to Tuberculin Induced by Bacille Calmette‐Guérin Vaccination in Northern Malawi" @default.
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- W2098362022 doi "https://doi.org/10.1086/342416" @default.
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