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- W2098375330 abstract "Submucosal cholinergic and noncholinergic neurons in intestines have been shown to be involved in regulating epithelial transport functions, particularly stimulating Cl − secretion. This study investigates the role of submucosal cholinergic neurons in regulating electrogenic Na + absorption in distal colon. Amiloride-sensitive short-circuit current ( I sc ) and 22 Na + flux were measured in mucosal and mucosal-submucosal preparations mounted in Ussing chambers. In the mucosal preparation, carbachol (CCh) added to the serosal side inhibited amiloride-sensitive I sc and amiloride-sensitive 22 Na + absorption. The inhibitory effect of CCh was observed at ∼0.1 μM, and maximum inhibition of ∼70% was attained at ∼30 μM (IC 50 = ∼1 μM). CCh-induced inhibition of amiloride-sensitive I sc was almost totally abolished by 10 μM atropine. Treatment of the tissue with ionomycin markedly reduced amiloride-sensitive I sc , but a subsequent addition of CCh further decreased it. Also, CCh still had an inhibitory effect, although significantly attenuated, after the tissue had been incubated with a low-Ca 2+ solution containing ionomycin and BAPTA-AM. Applying electrical field stimulation to submucosal neurons in the mucosal-submucosal preparation resulted in inhibition of amiloride-sensitive I sc , ∼33% of this inhibition being atropine sensitive. Physostigmine inhibited amiloride-sensitive I sc , this effect being abolished by atropine. In conclusion, submucosal cholinergic and noncholinergic neurons were involved in inhibiting electrogenic Na + absorption in colon. This inhibition by cholinergic neurons was mediated by muscarinic receptor activation." @default.
- W2098375330 created "2016-06-24" @default.
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- W2098375330 date "2003-04-01" @default.
- W2098375330 modified "2023-09-23" @default.
- W2098375330 title "Cholinergic inhibition of electrogenic sodium absorption in the guinea pig distal colon" @default.
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- W2098375330 doi "https://doi.org/10.1152/ajpgi.00201.2002" @default.
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