FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098380546> ?p ?o ?g. }

• W2098380546 endingPage "30" @default.
• W2098380546 startingPage "1" @default.
• W2098380546 abstract "The synthetic immunomodulator AS101[ammonium trichloro(dioxoethylene-o,o')tellurate] was previously found to protect cancer patients from chemotherapy-induced bone marrow toxicity and alopecia. Here we show that AS101 induces hair growth in nude and normal mice. AS101 possesses the dual ability to both induce anagen and retard spontaneous catagen in the C57BL/6 mouse model. Anagen induced by AS101 is mediated by keratinocyte growth factor (KGF), as it is abrogated both in nude mice co-treated with AS101 plus neutralizing anti KGF antibodies and in AS101-treated transgenic mice expressing a dominant-negative KGF receptor transgene in basal keratinocytes. AS101 up-regulates KGF expression by activating the ras signaling pathway in cultured fibroblasts. AS101-induced delayed catagen is associated with inhibition of terminal differentiation marker expression both in nude and C57BL/6 mice epidermal follicular keratinocytes and in cultures of primary mouse follicular keratinocytes induced to differentiate. This activity is associated with relatively sustained elevation of p21waf. Delayed expression of terminal differentiation markers was not induced by AS101 in follicular keratinocytes from p21waf knockout mice. Because similar results were obtained with cultures of primary human keratinocytes and fibroblasts, preliminary case report studies revealed substantial hair growth when AS101 was topically applied on three adolescents who had remained alopeciac 1-2 years after chemotherapy. The results emphasize the unique mode of action of AS101 and highlight its potential clinical use for treating certain types of alopecia." @default.
• W2098380546 created "2016-06-24" @default.
• W2098380546 creator A5006017973 @default.
• W2098380546 creator A5010571731 @default.
• W2098380546 creator A5017351947 @default.
• W2098380546 creator A5037486292 @default.
• W2098380546 creator A5040480888 @default.
• W2098380546 creator A5060849682 @default.
• W2098380546 creator A5063744115 @default.
• W2098380546 creator A5065557474 @default.
• W2098380546 creator A5073323129 @default.
• W2098380546 creator A5088790613 @default.
• W2098380546 creator A5090103842 @default.
• W2098380546 date "2003-12-04" @default.
• W2098380546 modified "2023-09-24" @default.
• W2098380546 title "Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression" @default.
• W2098380546 cites W1484778370 @default.
• W2098380546 cites W1550147049 @default.
• W2098380546 cites W1599263328 @default.
• W2098380546 cites W1606711804 @default.
• W2098380546 cites W1609524256 @default.
• W2098380546 cites W1911326922 @default.
• W2098380546 cites W1979388174 @default.
• W2098380546 cites W1980473267 @default.
• W2098380546 cites W1982549664 @default.
• W2098380546 cites W1984821767 @default.
• W2098380546 cites W1986845238 @default.
• W2098380546 cites W1998829686 @default.
• W2098380546 cites W2009900140 @default.
• W2098380546 cites W2024100063 @default.
• W2098380546 cites W2047189969 @default.
• W2098380546 cites W2051613486 @default.
• W2098380546 cites W2056687480 @default.
• W2098380546 cites W2062036642 @default.
• W2098380546 cites W2062763609 @default.
• W2098380546 cites W2063964407 @default.
• W2098380546 cites W2067762665 @default.
• W2098380546 cites W2081337067 @default.
• W2098380546 cites W2082055267 @default.
• W2098380546 cites W2091841822 @default.
• W2098380546 cites W2093087883 @default.
• W2098380546 cites W2099583536 @default.
• W2098380546 cites W2111363882 @default.
• W2098380546 cites W2118991681 @default.
• W2098380546 cites W2128375455 @default.
• W2098380546 cites W2131986778 @default.
• W2098380546 cites W2157438849 @default.
• W2098380546 cites W2158080844 @default.
• W2098380546 cites W2253280322 @default.
• W2098380546 cites W2318163251 @default.
• W2098380546 cites W2401084515 @default.
• W2098380546 cites W2444166999 @default.
• W2098380546 cites W4874447 @default.
• W2098380546 doi "https://doi.org/10.1096/fj.03-0552fje" @default.
• W2098380546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14656992" @default.
• W2098380546 hasPublicationYear "2003" @default.
• W2098380546 type Work @default.
• W2098380546 sameAs 2098380546 @default.
• W2098380546 citedByCount "51" @default.
• W2098380546 countsByYear W20983805462012 @default.
• W2098380546 countsByYear W20983805462013 @default.
• W2098380546 countsByYear W20983805462014 @default.
• W2098380546 countsByYear W20983805462015 @default.
• W2098380546 countsByYear W20983805462016 @default.
• W2098380546 countsByYear W20983805462017 @default.
• W2098380546 countsByYear W20983805462018 @default.
• W2098380546 countsByYear W20983805462019 @default.
• W2098380546 countsByYear W20983805462020 @default.
• W2098380546 countsByYear W20983805462021 @default.
• W2098380546 countsByYear W20983805462022 @default.
• W2098380546 crossrefType "journal-article" @default.
• W2098380546 hasAuthorship W2098380546A5006017973 @default.
• W2098380546 hasAuthorship W2098380546A5010571731 @default.
• W2098380546 hasAuthorship W2098380546A5017351947 @default.
• W2098380546 hasAuthorship W2098380546A5037486292 @default.
• W2098380546 hasAuthorship W2098380546A5040480888 @default.
• W2098380546 hasAuthorship W2098380546A5060849682 @default.
• W2098380546 hasAuthorship W2098380546A5063744115 @default.
• W2098380546 hasAuthorship W2098380546A5065557474 @default.
• W2098380546 hasAuthorship W2098380546A5073323129 @default.
• W2098380546 hasAuthorship W2098380546A5088790613 @default.
• W2098380546 hasAuthorship W2098380546A5090103842 @default.
• W2098380546 hasConcept C126322002 @default.
• W2098380546 hasConcept C134018914 @default.
• W2098380546 hasConcept C170493617 @default.
• W2098380546 hasConcept C185592680 @default.
• W2098380546 hasConcept C187785154 @default.
• W2098380546 hasConcept C2775960820 @default.
• W2098380546 hasConcept C2777074287 @default.
• W2098380546 hasConcept C2777216303 @default.
• W2098380546 hasConcept C2778615670 @default.
• W2098380546 hasConcept C502942594 @default.
• W2098380546 hasConcept C54355233 @default.
• W2098380546 hasConcept C71924100 @default.
• W2098380546 hasConcept C81885089 @default.
• W2098380546 hasConcept C86803240 @default.
• W2098380546 hasConcept C95444343 @default.
• W2098380546 hasConceptScore W2098380546C126322002 @default.

• next