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- W2098381491 endingPage "731" @default.
- W2098381491 startingPage "717" @default.
- W2098381491 abstract "Pharmacokinetics seeks to provide a mathematical basis for the description and prediction of the time-course of drugs in the body and an understanding of the processes involved in drug absorption and disposition. In the context of regional anaesthesia, the application of kinetic principles helps specifically in the following ways: (1) To select safe doses for single anaesthetic procedures and safe rates for continuous nerve block techniques. (2) To choose the best agents for particular procedures. (3) To identify patients who may be at particular risk of developing systemic toxic reactions. (4) To understand events after inadvertent intravascular injection. In addition, knowledge of the pharmacokinetics of existing agents should contribute to the design of better local anaesthetics in the future. This review will concentrate on aspects of the systemic absorption and disposition of local anaesthetics. Processes involved in the local disposition of the agents at and near the site of injection also come under the heading of pharmacokinetics. However, understanding of these phenomena is more speculative, since it is based primarily upon spatio-temporal changes in anaesthetic effect, rather than chemical measurements. The reader is referred to reviews by Greene (1983,1985) and Tucker and Mather (1980,1986) for discussion of these aspects." @default.
- W2098381491 created "2016-06-24" @default.
- W2098381491 creator A5026746931 @default.
- W2098381491 date "1986-07-01" @default.
- W2098381491 modified "2023-09-30" @default.
- W2098381491 title "PHARAMACOKINETICS OF LOCAL ANAESTHETICS" @default.
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