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• W2098388627 abstract "Background and Objectives We investigated outcomes in a UK neonatal cohort as a benchmark for care of children with sickle cell disease (SCD).Design and Methods Two-hundred and fifty-two children (180 with hemoglobin [Hb] SS, 64 with HbSC, and 8 with HbS/β thalassemia), identified during 1983–2005 by universal birth screening in East London, were followed in a hospital and community-based program which included penicillin V prophylaxis from 3 months of age, 23-valent pneumococcal polysaccharide vaccine from 1993, conjugate pneumococcal vaccine from 2002 and transcranial Doppler screening from 1991.Results At the end of 2005, there were 2158 patient years of observation. The median age of the patients was 7.8 (interquartile range 3.3–13.0) years, and 2.8% of those enrolled had been lost to follow-up. The estimated survival of children with HbSS at 16 years was 99.0% (95% confidence interval, CI, 93.2 to 99.9%) and pneumococcal sepsis rate was 0.3 (95% CI 0.1–0.8) episodes per 100 patient-years. The risk of overt stroke was 4.3% (95%CI 1.5 to 11.4%) and could be further reduced by transcranial Doppler screening from infancy and transfusing all children with high-risk scans. No deaths, strokes or episodes of pneumococcal sepsis were observed in children with HbSC or HbS/β thalassemia. The mortality rates from HbSS were significantly lower than those in other reported cohorts.Interpretation and Conclusions Mortality in childhood SCD can virtually be eliminated in a well-resourced health service setting linking community-based care with a specialized, hospital-based center. SCD continues to cause substantial morbidity from acute complications and chronic organ damage. We recommend setting up of clinical networks to optimize the management of SCD." @default.
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• W2098388627 date "2007-07-01" @default.
• W2098388627 modified "2023-10-10" @default.
• W2098388627 title "Clinical outcomes in children with sickle cell disease living in England: a neonatal cohort in East London" @default.
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• W2098388627 doi "https://doi.org/10.3324/haematol.10937" @default.
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