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• W2098391569 abstract "The transition from naïve to activated T cells is marked by alternative splicing of pre-mRNA encoding the transmembrane phosphatase CD45. Using a short hairpin RNA interference screen, we identified heterogeneous ribonucleoprotein L-like (hnRNPLL) as a critical inducible regulator of CD45 alternative splicing. HnRNPLL was up-regulated in stimulated T cells, bound CD45 transcripts, and was both necessary and sufficient for CD45 alternative splicing. Depletion or overexpression of hnRNPLL in B and T cell lines and primary T cells resulted in reciprocal alteration of CD45RA and RO expression. Exon array analysis suggested that hnRNPLL acts as a global regulator of alternative splicing in activated T cells. Induction of hnRNPLL during hematopoietic cell activation and differentiation may allow cells to rapidly shift their transcriptomes to favor proliferation and inhibit cell death." @default.
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• W2098391569 date "2008-08-01" @default.
• W2098391569 modified "2023-10-15" @default.
• W2098391569 title "Regulation of CD45 Alternative Splicing by Heterogeneous Ribonucleoprotein, hnRNPLL" @default.
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• W2098391569 doi "https://doi.org/10.1126/science.1157610" @default.
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