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- W2098399059 abstract "Regional cerebral blood flow (rCBF) was measured by the 133Xe inhalation technique in 9 patients with Parkinson's disease and in 1 patient with pure akinesia before and during treatment with l-threo-3,4-dihydroxyphenylserine (DOPS). l-DOPS alone was administered in 4 patients, and combined with l-DOPA or bromocriptin in 6 patients. The mean, hemispheric and regional CBF was unaffected by the chronic administration of l-DOPS. In addition, no significant difference in the mean CBF was observed between the patients who showed marked or moderate improvement in parkinsonian symptoms during the treatment with l-DOPS and those who showed slight improvement or no change, or between the group treated with l-DOPS alone and the group treated in combination with l-DOPS and other drugs. These results indicate that l-DOPS does not increase the CBF in parkinsonian patients, thus the anti-parkinsonian effects of the agent are not mediated by changes in CBF." @default.
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- W2098399059 date "1988-01-01" @default.
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- W2098399059 title "Effect of l-threo-3,4-dihydroxyphenylserine on regional cerebral blood flow in patients with Parkinson's disease" @default.
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- W2098399059 doi "https://doi.org/10.1016/0022-510x(88)90021-4" @default.
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