Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098412054> ?p ?o ?g. }
- W2098412054 endingPage "1614" @default.
- W2098412054 startingPage "1605" @default.
- W2098412054 abstract "The major role of glucagon is to promote hepatic gluconeogenesis and glycogenolysis to raise blood glucose levels during hypoglycemic conditions. Several animal models have been established to examine the in vivo function of glucagon in the liver through attenuation of glucagon via glucagon receptor knockout animals and pharmacological interventions. To investigate the consequences of glucagon loss to hepatic glucose production and glucose homeostasis, we derived mice with a pancreas specific ablation of the α-cell transcription factor, Arx, resulting in a complete loss of the glucagon-producing pancreatic α-cell. Using this model, we found that glucagon is not required for the general health of mice but is essential for total hepatic glucose production. Our data clarifies the importance of glucagon during the regulation of fasting and postprandial glucose homeostasis." @default.
- W2098412054 created "2016-06-24" @default.
- W2098412054 creator A5007977122 @default.
- W2098412054 creator A5043344689 @default.
- W2098412054 creator A5051500777 @default.
- W2098412054 creator A5085610048 @default.
- W2098412054 creator A5087625068 @default.
- W2098412054 date "2010-08-01" @default.
- W2098412054 modified "2023-10-18" @default.
- W2098412054 title "Glucagon Deficiency Reduces Hepatic Glucose Production and Improves Glucose Tolerance In Adult Mice" @default.
- W2098412054 cites W1964422326 @default.
- W2098412054 cites W1976086374 @default.
- W2098412054 cites W1988784323 @default.
- W2098412054 cites W1990607211 @default.
- W2098412054 cites W1996876777 @default.
- W2098412054 cites W2000047954 @default.
- W2098412054 cites W2002744316 @default.
- W2098412054 cites W2005574862 @default.
- W2098412054 cites W2025243241 @default.
- W2098412054 cites W2026863707 @default.
- W2098412054 cites W2036141586 @default.
- W2098412054 cites W2036334886 @default.
- W2098412054 cites W2040801017 @default.
- W2098412054 cites W2046005171 @default.
- W2098412054 cites W2053234614 @default.
- W2098412054 cites W2055421069 @default.
- W2098412054 cites W2057361172 @default.
- W2098412054 cites W2057537453 @default.
- W2098412054 cites W2059719062 @default.
- W2098412054 cites W2095995901 @default.
- W2098412054 cites W2101199896 @default.
- W2098412054 cites W2102478516 @default.
- W2098412054 cites W2102597208 @default.
- W2098412054 cites W2103391067 @default.
- W2098412054 cites W2107037674 @default.
- W2098412054 cites W2110760195 @default.
- W2098412054 cites W2111611857 @default.
- W2098412054 cites W2113667153 @default.
- W2098412054 cites W2120210676 @default.
- W2098412054 cites W2127167047 @default.
- W2098412054 cites W2135531598 @default.
- W2098412054 cites W2136585808 @default.
- W2098412054 cites W2144536242 @default.
- W2098412054 cites W2146074741 @default.
- W2098412054 cites W2152578678 @default.
- W2098412054 cites W2168726045 @default.
- W2098412054 cites W2328089478 @default.
- W2098412054 doi "https://doi.org/10.1210/me.2010-0120" @default.
- W2098412054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2940466" @default.
- W2098412054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20592160" @default.
- W2098412054 hasPublicationYear "2010" @default.
- W2098412054 type Work @default.
- W2098412054 sameAs 2098412054 @default.
- W2098412054 citedByCount "78" @default.
- W2098412054 countsByYear W20984120542012 @default.
- W2098412054 countsByYear W20984120542013 @default.
- W2098412054 countsByYear W20984120542014 @default.
- W2098412054 countsByYear W20984120542015 @default.
- W2098412054 countsByYear W20984120542016 @default.
- W2098412054 countsByYear W20984120542017 @default.
- W2098412054 countsByYear W20984120542018 @default.
- W2098412054 countsByYear W20984120542019 @default.
- W2098412054 countsByYear W20984120542020 @default.
- W2098412054 countsByYear W20984120542021 @default.
- W2098412054 countsByYear W20984120542022 @default.
- W2098412054 countsByYear W20984120542023 @default.
- W2098412054 crossrefType "journal-article" @default.
- W2098412054 hasAuthorship W2098412054A5007977122 @default.
- W2098412054 hasAuthorship W2098412054A5043344689 @default.
- W2098412054 hasAuthorship W2098412054A5051500777 @default.
- W2098412054 hasAuthorship W2098412054A5085610048 @default.
- W2098412054 hasAuthorship W2098412054A5087625068 @default.
- W2098412054 hasBestOaLocation W20984120541 @default.
- W2098412054 hasConcept C126322002 @default.
- W2098412054 hasConcept C134018914 @default.
- W2098412054 hasConcept C165220095 @default.
- W2098412054 hasConcept C20904676 @default.
- W2098412054 hasConcept C2776828364 @default.
- W2098412054 hasConcept C2777300450 @default.
- W2098412054 hasConcept C2777391703 @default.
- W2098412054 hasConcept C2777949327 @default.
- W2098412054 hasConcept C2778199505 @default.
- W2098412054 hasConcept C2778542361 @default.
- W2098412054 hasConcept C2778563252 @default.
- W2098412054 hasConcept C2778764654 @default.
- W2098412054 hasConcept C2779306644 @default.
- W2098412054 hasConcept C3018667095 @default.
- W2098412054 hasConcept C555293320 @default.
- W2098412054 hasConcept C62231903 @default.
- W2098412054 hasConcept C63645605 @default.
- W2098412054 hasConcept C71924100 @default.
- W2098412054 hasConcept C86803240 @default.
- W2098412054 hasConceptScore W2098412054C126322002 @default.
- W2098412054 hasConceptScore W2098412054C134018914 @default.
- W2098412054 hasConceptScore W2098412054C165220095 @default.
- W2098412054 hasConceptScore W2098412054C20904676 @default.
- W2098412054 hasConceptScore W2098412054C2776828364 @default.
- W2098412054 hasConceptScore W2098412054C2777300450 @default.