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- W2098431098 abstract "Small interfering RNA (siRNA), a 21-23nt double-stranded RNA responsible for post-transcriptional gene silencing, has attracted great interests as promising genomic drugs, due to its strong ability to silence target genes in a sequence-specific manner. Despite high silencing efficiency and on-target specificity, the clinical translation of siRNA has been hindered by its inherent features: poor intracellular delivery, limited blood stability, unpredictable immune responses and unwanted off-targeting effects. To overcome these hindrances, researchers have made various advances to modify siRNA itself and to improve its delivery. In this review paper, first we briefly discuss the innate properties and delivery barriers of siRNA. Then, we describe recent progress in (1) chemically and structurally modified siRNAs to solve their intrinsic problems and (2) siRNA delivery formulations including siRNA conjugates, polymerized siRNA, and nucleic acid-based nanoparticles to improve in vivo delivery." @default.
- W2098431098 created "2016-06-24" @default.
- W2098431098 creator A5002239807 @default.
- W2098431098 creator A5027660691 @default.
- W2098431098 creator A5030417895 @default.
- W2098431098 creator A5055447223 @default.
- W2098431098 creator A5056431102 @default.
- W2098431098 date "2016-09-01" @default.
- W2098431098 modified "2023-10-14" @default.
- W2098431098 title "Chemical and structural modifications of RNAi therapeutics" @default.
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