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• W2098454086 abstract "The effect of the natural product diindolylmethane (DIM) on cytosolic Ca 2+ concentrations ([Ca 2+ ] i ) and viability in MDCK renal tubular cells was explored. The Ca 2+ -sensitive fluorescent dye fura-2 was applied to measure [Ca 2+ ] i . DIM at concentrations 1–50 μM induced a [Ca 2+ ] i rise in a concentration-dependent manner. The response was reduced partly by removing Ca 2+ . DIM induced Mn 2+ influx leading to quenching of fura-2 fluorescence. DIM-evoked Ca 2+ entry was suppressed by nifedipine, econazole, SK&F96365 and protein kinase C modulators. In the absence of extracellular Ca 2+ , incubation with the endoplasmic reticulum Ca 2+ pump inhibitor thapsigargin (TG) or 2,5-di-tert-butylhydroquinone (BHQ) greatly inhibited DIM-induced [Ca 2+ ] i rise. Incubation with DIM abolished TG or BHQ-induced [Ca 2+ ] i rise. Inhibition of phospholipase C with U73122 reduced DIM-induced [Ca 2+ ] i rise by 50%. At 1, 10, 40 and 50 μM, DIM slightly enhanced cell proliferation. The effect of 50 μM DIM was reversed by chelating cytosolic Ca 2+ with 1,2-bis(2-aminophenoxy)ethane- N, N, N', N'-tetraacetic acid. In sum, in MDCK cells, DIM induced a [Ca 2+ ] i rise by evoking phospholipase C-dependent Ca 2+ release from the endoplasmic reticulum and Ca 2+ entry via protein kinase C-sensitive store-operated Ca 2+ channels. DIM did not induce cell death." @default.
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• W2098454086 date "2012-11-29" @default.
• W2098454086 modified "2023-09-26" @default.
• W2098454086 title "Effect of diindolylmethane on Ca²⁺ homeostasis and viability in MDCK renal tubular cells" @default.
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• W2098454086 doi "https://doi.org/10.1177/0960327112462727" @default.
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