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• W2098481330 abstract "ABSTRACT Mounting evidence suggests that human immunodeficiency virus type 1 (HIV-1) Gag-specific T helper cells contribute to effective antiviral control, but their functional characteristics and the precise epitopes targeted by this response remain to be defined. In this study, we generated CD4 + T-cell clones specific for Gag from HIV-1-infected persons with vigorous Gag-specific responses detectable in peripheral blood mononuclear cells. Multiple peptides containing T helper epitopes were identified, including a minimal peptide, VHAGPIAG (amino acids 218 to 226), in the cyclophilin binding domain of Gag. Peptide recognition by all clones examined induced cell proliferation, gamma interferon (IFN-γ) secretion, and cytolytic activity. Cytolysis was abrogated by concanamycin A and EGTA but not brefeldin A or anti-Fas antibody, implying a perforin-mediated mechanism of cell lysis. Additionally, serine esterase release into the extracellular medium, a marker for cytolytic granules, was demonstrated in an antigen-specific, dose-dependent fashion. These data indicate that T helper cells can target multiple regions of the p24 Gag protein and suggest that cytolytic activity may be a component of the antiviral effect of these cells." @default.
• W2098481330 created "2016-06-24" @default.
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• W2098481330 date "2001-10-15" @default.
• W2098481330 modified "2023-10-09" @default.
• W2098481330 title "Multiple Effector Functions Mediated by Human Immunodeficiency Virus-Specific CD4⁺T-Cell Clones" @default.
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• W2098481330 doi "https://doi.org/10.1128/jvi.75.20.9771-9779.2001" @default.
• W2098481330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/114549" @default.
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