Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098487788> ?p ?o ?g. }
- W2098487788 endingPage "1018" @default.
- W2098487788 startingPage "1013" @default.
- W2098487788 abstract "ABSTRACT Peptides derived from the α-helical domains of human immunodeficiency virus (HIV) type 1 (HIV-1) gp41 inhibit HIV-1 fusion to the cell membrane. Enfuvirtide (T-20) is a peptide-based drug that targets the step of HIV fusion, and as such, it effectively suppresses the replication of HIV-1 strains that are either wild type or resistant to multiple reverse transcriptase and/or protease inhibitors. However, HIV-1 variants with T-20 resistance have emerged; therefore, the development of new and potent inhibitors is urgently needed. We have developed a novel HIV fusion inhibitor, SC34EK, which is a gp41-derived 34-amino-acid peptide with glutamate (E) and lysine (K) substitutions on its solvent-accessible site that stabilize its α-helicity. Importantly, SC34EK effectively inhibits the replication of T-20-resistant HIV-1 strains as well as wild-type HIV-1. In this report, we introduce SC29EK, a 29-amino-acid peptide that is a shorter variant of SC34EK. SC29EK blocked the replication of T-20-resistant HIV-1 strains and maintained antiviral activity even in the presence of high serum concentrations (up to 50%). Circular dichroism analysis revealed that the α-helicity of SC29EK was well maintained, while that of the parental peptide, C29, which showed moderate and reduced inhibition of wild-type and T-20-resistant HIV-1 strains, was lower. Our results show that the α-helicity in a peptide-based fusion inhibitor is a key factor for activity and enables the design of short peptide inhibitors with improved pharmacological properties." @default.
- W2098487788 created "2016-06-24" @default.
- W2098487788 creator A5007153206 @default.
- W2098487788 creator A5008086835 @default.
- W2098487788 creator A5014781635 @default.
- W2098487788 creator A5019527890 @default.
- W2098487788 creator A5033128839 @default.
- W2098487788 creator A5041513558 @default.
- W2098487788 creator A5063339600 @default.
- W2098487788 creator A5063947250 @default.
- W2098487788 creator A5065647772 @default.
- W2098487788 creator A5067992113 @default.
- W2098487788 creator A5073716313 @default.
- W2098487788 date "2009-03-01" @default.
- W2098487788 modified "2023-10-18" @default.
- W2098487788 title "SC29EK, a Peptide Fusion Inhibitor with Enhanced α-Helicity, Inhibits Replication of Human Immunodeficiency Virus Type 1 Mutants Resistant to Enfuvirtide" @default.
- W2098487788 cites W1480555318 @default.
- W2098487788 cites W1537640815 @default.
- W2098487788 cites W1659719610 @default.
- W2098487788 cites W1973984443 @default.
- W2098487788 cites W1994081152 @default.
- W2098487788 cites W1998885242 @default.
- W2098487788 cites W2001754861 @default.
- W2098487788 cites W2023270608 @default.
- W2098487788 cites W2027738518 @default.
- W2098487788 cites W2030648131 @default.
- W2098487788 cites W2034073194 @default.
- W2098487788 cites W2040506631 @default.
- W2098487788 cites W2043448829 @default.
- W2098487788 cites W2067967208 @default.
- W2098487788 cites W2085739552 @default.
- W2098487788 cites W2086382266 @default.
- W2098487788 cites W2087082736 @default.
- W2098487788 cites W2091847883 @default.
- W2098487788 cites W2094653484 @default.
- W2098487788 cites W2100086384 @default.
- W2098487788 cites W2111610276 @default.
- W2098487788 cites W2112131257 @default.
- W2098487788 cites W2123797944 @default.
- W2098487788 cites W2129160108 @default.
- W2098487788 cites W2133649749 @default.
- W2098487788 cites W2146478787 @default.
- W2098487788 cites W2151273118 @default.
- W2098487788 cites W2154764173 @default.
- W2098487788 cites W2172221687 @default.
- W2098487788 cites W2321460134 @default.
- W2098487788 cites W4237410627 @default.
- W2098487788 doi "https://doi.org/10.1128/aac.01211-08" @default.
- W2098487788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2650564" @default.
- W2098487788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19114674" @default.
- W2098487788 hasPublicationYear "2009" @default.
- W2098487788 type Work @default.
- W2098487788 sameAs 2098487788 @default.
- W2098487788 citedByCount "74" @default.
- W2098487788 countsByYear W20984877882012 @default.
- W2098487788 countsByYear W20984877882013 @default.
- W2098487788 countsByYear W20984877882014 @default.
- W2098487788 countsByYear W20984877882015 @default.
- W2098487788 countsByYear W20984877882016 @default.
- W2098487788 countsByYear W20984877882017 @default.
- W2098487788 countsByYear W20984877882018 @default.
- W2098487788 countsByYear W20984877882019 @default.
- W2098487788 countsByYear W20984877882020 @default.
- W2098487788 countsByYear W20984877882021 @default.
- W2098487788 crossrefType "journal-article" @default.
- W2098487788 hasAuthorship W2098487788A5007153206 @default.
- W2098487788 hasAuthorship W2098487788A5008086835 @default.
- W2098487788 hasAuthorship W2098487788A5014781635 @default.
- W2098487788 hasAuthorship W2098487788A5019527890 @default.
- W2098487788 hasAuthorship W2098487788A5033128839 @default.
- W2098487788 hasAuthorship W2098487788A5041513558 @default.
- W2098487788 hasAuthorship W2098487788A5063339600 @default.
- W2098487788 hasAuthorship W2098487788A5063947250 @default.
- W2098487788 hasAuthorship W2098487788A5065647772 @default.
- W2098487788 hasAuthorship W2098487788A5067992113 @default.
- W2098487788 hasAuthorship W2098487788A5073716313 @default.
- W2098487788 hasBestOaLocation W20984877881 @default.
- W2098487788 hasConcept C103038307 @default.
- W2098487788 hasConcept C104317684 @default.
- W2098487788 hasConcept C124790011 @default.
- W2098487788 hasConcept C140704245 @default.
- W2098487788 hasConcept C142462285 @default.
- W2098487788 hasConcept C143065580 @default.
- W2098487788 hasConcept C153911025 @default.
- W2098487788 hasConcept C156719811 @default.
- W2098487788 hasConcept C159047783 @default.
- W2098487788 hasConcept C159654299 @default.
- W2098487788 hasConcept C181199279 @default.
- W2098487788 hasConcept C195616568 @default.
- W2098487788 hasConcept C2522874641 @default.
- W2098487788 hasConcept C2776258796 @default.
- W2098487788 hasConcept C2776714187 @default.
- W2098487788 hasConcept C2778037500 @default.
- W2098487788 hasConcept C2779281246 @default.
- W2098487788 hasConcept C2779298103 @default.
- W2098487788 hasConcept C2993143319 @default.
- W2098487788 hasConcept C515207424 @default.
- W2098487788 hasConcept C54355233 @default.