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• W2098489923 abstract "Abstract The Ag-specific interactions between T cells and dendritic cells progress through dynamic contact stages in vivo consisting of early long-term stable contacts and later confined, yet motile, short-lived contacts. The signaling pathways that control in vivo interaction dynamics between T cells and dendritic cells during priming remain undefined. Adhesion and degranulation promoting adapter protein (ADAP) is a multifunctional adapter that regulates “inside-out” signaling from the TCR to integrins. Using two-photon microscopy, we demonstrate that, in the absence of ADAP, CD4 T cells make fewer early-stage stable contacts with Ag-laden dendritic cells, and the interactions are characterized by brief repetitive contacts. Furthermore, ADAP-deficient T cells show reduced contacts at the late motile contact phase and display less confinement around dendritic cells. The altered T cell interaction dynamics in the absence of ADAP are associated with defective early proliferation and attenuated TCR signaling in vivo. Regulation of multistage contact behaviors and optimal T cell signaling involves the interaction of ADAP with the adapter src kinase–associated phosphoprotein of 55 kDa (SKAP55). Thus, integrin activation by the ADAP-SKAP55–signaling module controls the stability and duration of T cell–dendritic cell contacts during the progressive phases necessary for optimal T cell activation." @default.
• W2098489923 created "2016-06-24" @default.
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• W2098489923 date "2013-09-01" @default.
• W2098489923 modified "2023-10-16" @default.
• W2098489923 title "Multistage T Cell–Dendritic Cell Interactions Control Optimal CD4 T Cell Activation through the ADAP-SKAP55–Signaling Module" @default.
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• W2098489923 doi "https://doi.org/10.4049/jimmunol.1300107" @default.
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