FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098491091> ?p ?o ?g. }

• W2098491091 endingPage "742" @default.
• W2098491091 startingPage "727" @default.
• W2098491091 abstract "We examined the effects of a nonspecific ion channel blocker, bupivacaine, on K channels encoded by hERG, rKv1.4, rKv4.3, and hKvLQT1 along with hIsK. Their native counterparts in the heart are important for the function of I(Kr), I(to) and I(Ks) and, thus, play an important role in repolarization.To elucidate the mechanisms and sites of bupivacaine's actions, we correlated the voltage and time dependencies of drug effects with those of channel gating. We also studied the effects of altering the C-type (hERG) or N-type (rKv1.4) inactivation process or the subunit composition (hKvLQT1 with or without hIsK) on bupivacaine's actions. The results suggest that, except for hKvLQT1 co-expressed with hIsK, bupivacaine binding occurred at depolarized voltages coinciding with channel activation. With hKvLQT1 co-expressed with hIsK, bupivacaine bound preferentially at negative voltages when channels were in the closed state, and unbound at depolarized voltages when channels opened. The C-type inactivation of hERG enhanced, whereas the N-type inactivation of rKv1.4 hindered, bupivacaine's effects.We propose that bupivacaine's actions on these K channels can be described as a nonspecific pore blockade in the inner mouth region. However, the apparent binding affinity and voltage dependence of binding can be differentially influenced by the inactivation processes occurring at two ends of the pore (C-type inactivation at the outer end and N-type inactivation at the inner end), or by the interaction between hIsK and hKvLQT1 subunits." @default.
• W2098491091 created "2016-06-24" @default.
• W2098491091 creator A5003910726 @default.
• W2098491091 creator A5072793703 @default.
• W2098491091 creator A5084741755 @default.
• W2098491091 date "1998-07-01" @default.
• W2098491091 modified "2023-09-26" @default.
• W2098491091 title "Differential Effects of Bupivacaine on Cardiac K Channels: Role of Channel Inactivation and Subunit Composition in Drug?Channel Interaction" @default.
• W2098491091 cites W1964210830 @default.
• W2098491091 cites W1966667742 @default.
• W2098491091 cites W1968098810 @default.
• W2098491091 cites W1968371524 @default.
• W2098491091 cites W1983137097 @default.
• W2098491091 cites W1988577370 @default.
• W2098491091 cites W2002422701 @default.
• W2098491091 cites W2004001482 @default.
• W2098491091 cites W2006090981 @default.
• W2098491091 cites W2011581275 @default.
• W2098491091 cites W2019703459 @default.
• W2098491091 cites W2021438486 @default.
• W2098491091 cites W2024425652 @default.
• W2098491091 cites W2038375865 @default.
• W2098491091 cites W2043100598 @default.
• W2098491091 cites W2053351731 @default.
• W2098491091 cites W2056075302 @default.
• W2098491091 cites W2082585200 @default.
• W2098491091 cites W2082668900 @default.
• W2098491091 cites W2087306949 @default.
• W2098491091 cites W2097653225 @default.
• W2098491091 cites W2105230499 @default.
• W2098491091 cites W2108466800 @default.
• W2098491091 cites W2108765087 @default.
• W2098491091 cites W2115594095 @default.
• W2098491091 cites W2122508506 @default.
• W2098491091 cites W2126688997 @default.
• W2098491091 cites W2128473133 @default.
• W2098491091 cites W2133464980 @default.
• W2098491091 cites W2136463260 @default.
• W2098491091 cites W2165830038 @default.
• W2098491091 cites W2170819411 @default.
• W2098491091 cites W2323956997 @default.
• W2098491091 cites W2404672629 @default.
• W2098491091 cites W2495164068 @default.
• W2098491091 doi "https://doi.org/10.1111/j.1540-8167.1998.tb00960.x" @default.
• W2098491091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9684721" @default.
• W2098491091 hasPublicationYear "1998" @default.
• W2098491091 type Work @default.
• W2098491091 sameAs 2098491091 @default.
• W2098491091 citedByCount "24" @default.
• W2098491091 countsByYear W20984910912012 @default.
• W2098491091 countsByYear W20984910912014 @default.
• W2098491091 countsByYear W20984910912021 @default.
• W2098491091 crossrefType "journal-article" @default.
• W2098491091 hasAuthorship W2098491091A5003910726 @default.
• W2098491091 hasAuthorship W2098491091A5072793703 @default.
• W2098491091 hasAuthorship W2098491091A5084741755 @default.
• W2098491091 hasConcept C104292427 @default.
• W2098491091 hasConcept C104317684 @default.
• W2098491091 hasConcept C12554922 @default.
• W2098491091 hasConcept C126322002 @default.
• W2098491091 hasConcept C146403970 @default.
• W2098491091 hasConcept C170493617 @default.
• W2098491091 hasConcept C185263204 @default.
• W2098491091 hasConcept C185592680 @default.
• W2098491091 hasConcept C194544171 @default.
• W2098491091 hasConcept C2779362680 @default.
• W2098491091 hasConcept C2781328992 @default.
• W2098491091 hasConcept C50254741 @default.
• W2098491091 hasConcept C55493867 @default.
• W2098491091 hasConcept C71240020 @default.
• W2098491091 hasConcept C71924100 @default.
• W2098491091 hasConcept C83743174 @default.
• W2098491091 hasConcept C86803240 @default.
• W2098491091 hasConcept C98274493 @default.
• W2098491091 hasConceptScore W2098491091C104292427 @default.
• W2098491091 hasConceptScore W2098491091C104317684 @default.
• W2098491091 hasConceptScore W2098491091C12554922 @default.
• W2098491091 hasConceptScore W2098491091C126322002 @default.
• W2098491091 hasConceptScore W2098491091C146403970 @default.
• W2098491091 hasConceptScore W2098491091C170493617 @default.
• W2098491091 hasConceptScore W2098491091C185263204 @default.
• W2098491091 hasConceptScore W2098491091C185592680 @default.
• W2098491091 hasConceptScore W2098491091C194544171 @default.
• W2098491091 hasConceptScore W2098491091C2779362680 @default.
• W2098491091 hasConceptScore W2098491091C2781328992 @default.
• W2098491091 hasConceptScore W2098491091C50254741 @default.
• W2098491091 hasConceptScore W2098491091C55493867 @default.
• W2098491091 hasConceptScore W2098491091C71240020 @default.
• W2098491091 hasConceptScore W2098491091C71924100 @default.
• W2098491091 hasConceptScore W2098491091C83743174 @default.
• W2098491091 hasConceptScore W2098491091C86803240 @default.
• W2098491091 hasConceptScore W2098491091C98274493 @default.
• W2098491091 hasIssue "7" @default.
• W2098491091 hasLocation W20984910911 @default.
• W2098491091 hasLocation W20984910912 @default.
• W2098491091 hasOpenAccess W2098491091 @default.
• W2098491091 hasPrimaryLocation W20984910911 @default.
• W2098491091 hasRelatedWork W1987987627 @default.

• next