FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098492858> ?p ?o ?g. }

• W2098492858 endingPage "2730" @default.
• W2098492858 startingPage "2724" @default.
• W2098492858 abstract "Pemphigus vulgaris is a blistering disease associated with autoantibodies to the desmosomal adhesion protein, desmoglein 3. Genetic deficiency of desmoglein 3 in mice mimics autoimmunity to desmoglein 3 in pemphigus vulgaris, with mucosal-dominant blistering in the suprabasal layer of the epidermis. Mice with an epidermal-specific deletion of desmocollin 3, the other major desmosomal cadherin isoform expressed in the basal epidermis, develop suprabasal blisters in skin that are histologically identical to those observed in pemphigus vulgaris, suggesting that desmocollin 3 might be a target of autoantibodies in some pemphigus vulgaris patients. We now demonstrate that desmocollin 3 is an autoantigen in pemphigus vulgaris, illustrated in a patient with mucosal-dominant blistering. Six of 38 pemphigus vulgaris and one of 85 normal serum samples immunoprecipitate desmocollin 3 (P = 0.003). Incubation of patient IgG with human keratinocytes causes loss of intercellular adhesion, and adsorption with recombinant desmocollin 3 specifically prevents this pathogenic effect. Additionally, anti-desmocollin 3 sera cause loss of keratinocyte cell surface desmocollin 3, but not desmoglein 3 by immunofluorescence, indicating distinct cellular pathogenic effects in anti-desmocollin and anti-desmoglein pemphigus, despite their identical clinical presentations. These data demonstrate that desmocollin 3 is a pathogenic autoantigen in pemphigus vulgaris and suggest that pemphigus vulgaris is a histological reaction pattern that may result from autoimmunity to desmoglein 3, desmocollin 3, or both desmosomal cadherins." @default.
• W2098492858 created "2016-06-24" @default.
• W2098492858 creator A5003409611 @default.
• W2098492858 creator A5010257527 @default.
• W2098492858 creator A5010408098 @default.
• W2098492858 creator A5042296646 @default.
• W2098492858 creator A5045431309 @default.
• W2098492858 creator A5063220166 @default.
• W2098492858 creator A5077911168 @default.
• W2098492858 creator A5078739339 @default.
• W2098492858 creator A5080015762 @default.
• W2098492858 creator A5080324106 @default.
• W2098492858 creator A5082342374 @default.
• W2098492858 date "2010-12-01" @default.
• W2098492858 modified "2023-10-18" @default.
• W2098492858 title "Autoimmunity to Desmocollin 3 in Pemphigus Vulgaris" @default.
• W2098492858 cites W1970201566 @default.
• W2098492858 cites W1971386513 @default.
• W2098492858 cites W1973394766 @default.
• W2098492858 cites W1973625682 @default.
• W2098492858 cites W1976739389 @default.
• W2098492858 cites W1980659844 @default.
• W2098492858 cites W1985278228 @default.
• W2098492858 cites W1997009310 @default.
• W2098492858 cites W1997802716 @default.
• W2098492858 cites W2003636838 @default.
• W2098492858 cites W2010985545 @default.
• W2098492858 cites W2012250244 @default.
• W2098492858 cites W2028334176 @default.
• W2098492858 cites W2029455788 @default.
• W2098492858 cites W2030750387 @default.
• W2098492858 cites W2040189845 @default.
• W2098492858 cites W2043369953 @default.
• W2098492858 cites W2047478128 @default.
• W2098492858 cites W2063511489 @default.
• W2098492858 cites W2064020028 @default.
• W2098492858 cites W2073026991 @default.
• W2098492858 cites W2073118857 @default.
• W2098492858 cites W2089061164 @default.
• W2098492858 cites W2094756180 @default.
• W2098492858 cites W2100510877 @default.
• W2098492858 cites W2100905754 @default.
• W2098492858 cites W2104917355 @default.
• W2098492858 cites W2107925919 @default.
• W2098492858 cites W2108838261 @default.
• W2098492858 cites W2110332942 @default.
• W2098492858 cites W2115229273 @default.
• W2098492858 cites W2140002188 @default.
• W2098492858 cites W2142068606 @default.
• W2098492858 cites W2143413953 @default.
• W2098492858 cites W2150104849 @default.
• W2098492858 cites W2341373534 @default.
• W2098492858 cites W4238016904 @default.
• W2098492858 doi "https://doi.org/10.2353/ajpath.2010.100483" @default.
• W2098492858 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2993297" @default.
• W2098492858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20952584" @default.
• W2098492858 hasPublicationYear "2010" @default.
• W2098492858 type Work @default.
• W2098492858 sameAs 2098492858 @default.
• W2098492858 citedByCount "77" @default.
• W2098492858 countsByYear W20984928582012 @default.
• W2098492858 countsByYear W20984928582013 @default.
• W2098492858 countsByYear W20984928582014 @default.
• W2098492858 countsByYear W20984928582015 @default.
• W2098492858 countsByYear W20984928582016 @default.
• W2098492858 countsByYear W20984928582017 @default.
• W2098492858 countsByYear W20984928582018 @default.
• W2098492858 countsByYear W20984928582019 @default.
• W2098492858 countsByYear W20984928582020 @default.
• W2098492858 countsByYear W20984928582021 @default.
• W2098492858 countsByYear W20984928582022 @default.
• W2098492858 countsByYear W20984928582023 @default.
• W2098492858 crossrefType "journal-article" @default.
• W2098492858 hasAuthorship W2098492858A5003409611 @default.
• W2098492858 hasAuthorship W2098492858A5010257527 @default.
• W2098492858 hasAuthorship W2098492858A5010408098 @default.
• W2098492858 hasAuthorship W2098492858A5042296646 @default.
• W2098492858 hasAuthorship W2098492858A5045431309 @default.
• W2098492858 hasAuthorship W2098492858A5063220166 @default.
• W2098492858 hasAuthorship W2098492858A5077911168 @default.
• W2098492858 hasAuthorship W2098492858A5078739339 @default.
• W2098492858 hasAuthorship W2098492858A5080015762 @default.
• W2098492858 hasAuthorship W2098492858A5080324106 @default.
• W2098492858 hasAuthorship W2098492858A5082342374 @default.
• W2098492858 hasBestOaLocation W20984928581 @default.
• W2098492858 hasConcept C1491633281 @default.
• W2098492858 hasConcept C159654299 @default.
• W2098492858 hasConcept C163764329 @default.
• W2098492858 hasConcept C203014093 @default.
• W2098492858 hasConcept C2777074287 @default.
• W2098492858 hasConcept C2778757060 @default.
• W2098492858 hasConcept C2781313415 @default.
• W2098492858 hasConcept C2781327288 @default.
• W2098492858 hasConcept C2909223747 @default.
• W2098492858 hasConcept C2910519024 @default.
• W2098492858 hasConcept C54355233 @default.
• W2098492858 hasConcept C67326383 @default.
• W2098492858 hasConcept C81885089 @default.

• next