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- W2098493774 abstract "Apoptosis is an essential physiological process of elimination of destined cells during the development and differentiation or after damage from external stresses such as ionizing radiation or chemotherapeutic agents. Disruption of apoptosis is proved to cause various diseases including cancer. Among numerous molecules involved in diverse anti- or pro-apoptotic signaling pathways, NF-kappaB is one of the key factors controlling anti-apoptotic responses. Its anti-apoptotic effect is thought to be mediated through not only transcriptional activation of dependent genes but also by crosstalking with the JNK pathway. Oncogenic proteins such as Ret/PTC, Ras and BRAF can induce NF-kappaB activation making it an important change in thyroid cancer. A number of specific or non-specific NF-kappaB inhibitors have been tried to take over the cascade in in vitro and in vivo experiments. These agents can induce massive apoptosis especially in combination with radio- or chemotherapy. Current results suggest that the inhibition of the NF-kappaB may be a promising strategy for advanced thyroid cancer treatment but further investigations are warranted to develop specific and clinically effective NF-kappaB inhibitors in future." @default.
- W2098493774 created "2016-06-24" @default.
- W2098493774 creator A5061184430 @default.
- W2098493774 creator A5085279080 @default.
- W2098493774 creator A5088043523 @default.
- W2098493774 date "2007-07-01" @default.
- W2098493774 modified "2023-10-17" @default.
- W2098493774 title "Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer" @default.
- W2098493774 cites W1481925502 @default.
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- W2098493774 cites W1501881225 @default.
- W2098493774 cites W1552681886 @default.
- W2098493774 cites W1558367558 @default.
- W2098493774 cites W1563090311 @default.
- W2098493774 cites W1670226482 @default.
- W2098493774 cites W1966923590 @default.
- W2098493774 cites W1973862406 @default.
- W2098493774 cites W1974867042 @default.
- W2098493774 cites W1983398917 @default.
- W2098493774 cites W1983805610 @default.
- W2098493774 cites W1994236253 @default.
- W2098493774 cites W1995335649 @default.
- W2098493774 cites W1999141617 @default.
- W2098493774 cites W2001859978 @default.
- W2098493774 cites W2014922333 @default.
- W2098493774 cites W2027260180 @default.
- W2098493774 cites W2027372621 @default.
- W2098493774 cites W2028468660 @default.
- W2098493774 cites W2030916051 @default.
- W2098493774 cites W2032531389 @default.
- W2098493774 cites W2040491886 @default.
- W2098493774 cites W2041173282 @default.
- W2098493774 cites W2046056065 @default.
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- W2098493774 cites W2051759127 @default.
- W2098493774 cites W2051994734 @default.
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- W2098493774 cites W2080662424 @default.
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- W2098493774 cites W2081421763 @default.
- W2098493774 cites W2086189875 @default.
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- W2098493774 cites W2150233389 @default.
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- W2098493774 cites W2153616388 @default.
- W2098493774 cites W2160592202 @default.
- W2098493774 cites W2170236911 @default.
- W2098493774 cites W2314325548 @default.
- W2098493774 cites W2325387537 @default.
- W2098493774 cites W2329249786 @default.
- W2098493774 cites W2332387324 @default.
- W2098493774 cites W2404854108 @default.
- W2098493774 cites W2470223656 @default.
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- W2098493774 doi "https://doi.org/10.1590/s0004-27302007000500023" @default.
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