Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098494020> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2098494020 endingPage "963" @default.
- W2098494020 startingPage "958" @default.
- W2098494020 abstract "Antineuronal antibodies (ANAs) have been implicated in the pathophysiology of postinfectious movement disorders, such as Sydenham's chorea. However, their relevance in other movement disorders--in the absence of infectious triggers--remains much disputed. We sought to assess the frequency of ANAs in idiopathic Parkinson's disease (IPD) and to explore whether a specific phenotype is associated with the presence of ANAs. For this purpose, we recruited 76 IPD patients, 9 patients with genetic parkinsonism, and 10 with one of the parkinson-plus syndromes. They were all subjected to a comprehensive clinical review. In addition, 50 patients with non-extrapyramidal neurological disease and 30 healthy blood donors served as control populations. Blood samples were tested for the presence of ANAs with Western blotting, using recombinant proteins of the three putative antigens (aldolase C, neuron-specific enolase, and pyruvate kinase M1). We found these antibodies in 11.8% of the 76 IPD patients, which differed significantly from healthy controls (0%, P = 0.043), but nonsignificantly from patients with genetic parkinsonism (11.1%), with a parkinson-plus syndrome (10%), or from neurological disease controls (4%). With respect to relevant disease characteristics, IPD patients with or without ANAs were indistinguishable, except for atypical disease features (mainly early falls or freezing and marked Pisa syndrome), which were more frequent in the ANA-positive IPD group. We conclude that ANAs do not play a role in the majority of patients with IPD, but might be relevant in the pathogenesis of IPD with atypical features." @default.
- W2098494020 created "2016-06-24" @default.
- W2098494020 creator A5006055206 @default.
- W2098494020 creator A5014203878 @default.
- W2098494020 creator A5015754502 @default.
- W2098494020 creator A5037755042 @default.
- W2098494020 creator A5065151023 @default.
- W2098494020 creator A5070897359 @default.
- W2098494020 creator A5071626950 @default.
- W2098494020 date "2008-03-28" @default.
- W2098494020 modified "2023-09-24" @default.
- W2098494020 title "Antineuronal antibodies in Parkinson's disease" @default.
- W2098494020 cites W1963626598 @default.
- W2098494020 cites W1972859381 @default.
- W2098494020 cites W1992417808 @default.
- W2098494020 cites W1999150651 @default.
- W2098494020 cites W2020764142 @default.
- W2098494020 cites W2021098049 @default.
- W2098494020 cites W2034224258 @default.
- W2098494020 cites W2051993610 @default.
- W2098494020 cites W2055934664 @default.
- W2098494020 cites W2057649946 @default.
- W2098494020 cites W2059107387 @default.
- W2098494020 cites W2066614858 @default.
- W2098494020 cites W2075934384 @default.
- W2098494020 cites W2108064744 @default.
- W2098494020 cites W2112653387 @default.
- W2098494020 cites W2142418751 @default.
- W2098494020 cites W2148683100 @default.
- W2098494020 cites W2150280208 @default.
- W2098494020 cites W2165339984 @default.
- W2098494020 doi "https://doi.org/10.1002/mds.21929" @default.
- W2098494020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18383532" @default.
- W2098494020 hasPublicationYear "2008" @default.
- W2098494020 type Work @default.
- W2098494020 sameAs 2098494020 @default.
- W2098494020 citedByCount "16" @default.
- W2098494020 countsByYear W20984940202012 @default.
- W2098494020 countsByYear W20984940202013 @default.
- W2098494020 countsByYear W20984940202014 @default.
- W2098494020 countsByYear W20984940202015 @default.
- W2098494020 countsByYear W20984940202016 @default.
- W2098494020 countsByYear W20984940202018 @default.
- W2098494020 countsByYear W20984940202019 @default.
- W2098494020 countsByYear W20984940202020 @default.
- W2098494020 countsByYear W20984940202022 @default.
- W2098494020 crossrefType "journal-article" @default.
- W2098494020 hasAuthorship W2098494020A5006055206 @default.
- W2098494020 hasAuthorship W2098494020A5014203878 @default.
- W2098494020 hasAuthorship W2098494020A5015754502 @default.
- W2098494020 hasAuthorship W2098494020A5037755042 @default.
- W2098494020 hasAuthorship W2098494020A5065151023 @default.
- W2098494020 hasAuthorship W2098494020A5070897359 @default.
- W2098494020 hasAuthorship W2098494020A5071626950 @default.
- W2098494020 hasConcept C126322002 @default.
- W2098494020 hasConcept C203014093 @default.
- W2098494020 hasConcept C2776525014 @default.
- W2098494020 hasConcept C2778261627 @default.
- W2098494020 hasConcept C2778868616 @default.
- W2098494020 hasConcept C2779134260 @default.
- W2098494020 hasConcept C71924100 @default.
- W2098494020 hasConceptScore W2098494020C126322002 @default.
- W2098494020 hasConceptScore W2098494020C203014093 @default.
- W2098494020 hasConceptScore W2098494020C2776525014 @default.
- W2098494020 hasConceptScore W2098494020C2778261627 @default.
- W2098494020 hasConceptScore W2098494020C2778868616 @default.
- W2098494020 hasConceptScore W2098494020C2779134260 @default.
- W2098494020 hasConceptScore W2098494020C71924100 @default.
- W2098494020 hasIssue "7" @default.
- W2098494020 hasLocation W20984940201 @default.
- W2098494020 hasLocation W20984940202 @default.
- W2098494020 hasOpenAccess W2098494020 @default.
- W2098494020 hasPrimaryLocation W20984940201 @default.
- W2098494020 hasRelatedWork W2025044685 @default.
- W2098494020 hasRelatedWork W2026171569 @default.
- W2098494020 hasRelatedWork W2044092576 @default.
- W2098494020 hasRelatedWork W2050314741 @default.
- W2098494020 hasRelatedWork W2058726583 @default.
- W2098494020 hasRelatedWork W2093683022 @default.
- W2098494020 hasRelatedWork W2256991896 @default.
- W2098494020 hasRelatedWork W2418426020 @default.
- W2098494020 hasRelatedWork W2809278343 @default.
- W2098494020 hasRelatedWork W3126629817 @default.
- W2098494020 hasVolume "23" @default.
- W2098494020 isParatext "false" @default.
- W2098494020 isRetracted "false" @default.
- W2098494020 magId "2098494020" @default.
- W2098494020 workType "article" @default.