FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098497945> ?p ?o ?g. }

• W2098497945 abstract "Animal models are indispensable tools in studying the cause of human diseases and searching for the treatments. The scientific value of an animal model depends on the accurate mimicry of human diseases. The primary goal of the current study was to develop a cross-species method by using the animal models' expression data to evaluate the similarity to human diseases' and assess drug molecules' efficiency in drug research. Therefore, we hoped to reveal that it is feasible and useful to compare gene expression profiles across species in the studies of pathology, toxicology, drug repositioning, and drug action mechanism.We developed a cross-species analysis method to analyze animal models' similarity to human diseases and effectiveness in drug research by utilizing the existing animal gene expression data in the public database, and mined some meaningful information to help drug research, such as potential drug candidates, possible drug repositioning, side effects and analysis in pharmacology. New animal models could be evaluated by our method before they are used in drug discovery. We applied the method to several cases of known animal model expression profiles and obtained some useful information to help drug research. We found that trichostatin A and some other HDACs could have very similar response across cell lines and species at gene expression level. Mouse hypoxia model could accurately mimic the human hypoxia, while mouse diabetes drug model might have some limitation. The transgenic mouse of Alzheimer was a useful model and we deeply analyzed the biological mechanisms of some drugs in this case. In addition, all the cases could provide some ideas for drug discovery and drug repositioning.We developed a new cross-species gene expression module comparison method to use animal models' expression data to analyse the effectiveness of animal models in drug research. Moreover, through data integration, our method could be applied for drug research, such as potential drug candidates, possible drug repositioning, side effects and information about pharmacology." @default.
• W2098497945 created "2016-06-24" @default.
• W2098497945 creator A5008280608 @default.
• W2098497945 creator A5008390320 @default.
• W2098497945 creator A5014662537 @default.
• W2098497945 creator A5030659566 @default.
• W2098497945 creator A5040176184 @default.
• W2098497945 creator A5044131502 @default.
• W2098497945 creator A5056788729 @default.
• W2098497945 creator A5084581495 @default.
• W2098497945 date "2012-12-01" @default.
• W2098497945 modified "2023-10-15" @default.
• W2098497945 title "A cross-species analysis method to analyze animal models' similarity to human's disease state" @default.
• W2098497945 cites W1586128942 @default.
• W2098497945 cites W1964826115 @default.
• W2098497945 cites W1971319245 @default.
• W2098497945 cites W1973506879 @default.
• W2098497945 cites W1977518850 @default.
• W2098497945 cites W1979755982 @default.
• W2098497945 cites W1981936226 @default.
• W2098497945 cites W1982037430 @default.
• W2098497945 cites W1983973995 @default.
• W2098497945 cites W1984370974 @default.
• W2098497945 cites W1999513011 @default.
• W2098497945 cites W2001679453 @default.
• W2098497945 cites W2003816877 @default.
• W2098497945 cites W2005674716 @default.
• W2098497945 cites W2009766076 @default.
• W2098497945 cites W2016654742 @default.
• W2098497945 cites W2024161975 @default.
• W2098497945 cites W2037883697 @default.
• W2098497945 cites W2039725154 @default.
• W2098497945 cites W2040674242 @default.
• W2098497945 cites W2050101449 @default.
• W2098497945 cites W2069905837 @default.
• W2098497945 cites W2071610467 @default.
• W2098497945 cites W2078457917 @default.
• W2098497945 cites W2086671688 @default.
• W2098497945 cites W2094791588 @default.
• W2098497945 cites W2100482380 @default.
• W2098497945 cites W2104209550 @default.
• W2098497945 cites W2108740070 @default.
• W2098497945 cites W2111558270 @default.
• W2098497945 cites W2111945921 @default.
• W2098497945 cites W2117827532 @default.
• W2098497945 cites W2120129511 @default.
• W2098497945 cites W2121604817 @default.
• W2098497945 cites W2122523158 @default.
• W2098497945 cites W2129288498 @default.
• W2098497945 cites W2132660227 @default.
• W2098497945 cites W2133768972 @default.
• W2098497945 cites W2135029153 @default.
• W2098497945 cites W2135650301 @default.
• W2098497945 cites W2139511828 @default.
• W2098497945 cites W2144346184 @default.
• W2098497945 cites W2146727483 @default.
• W2098497945 cites W2148498486 @default.
• W2098497945 cites W2150611256 @default.
• W2098497945 cites W2153474081 @default.
• W2098497945 cites W2154044807 @default.
• W2098497945 cites W2158054743 @default.
• W2098497945 cites W2158684024 @default.
• W2098497945 cites W2163978483 @default.
• W2098497945 cites W2165151093 @default.
• W2098497945 cites W2240146123 @default.
• W2098497945 cites W96512182 @default.
• W2098497945 doi "https://doi.org/10.1186/1752-0509-6-s3-s18" @default.
• W2098497945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3524072" @default.
• W2098497945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23282076" @default.
• W2098497945 hasPublicationYear "2012" @default.
• W2098497945 type Work @default.
• W2098497945 sameAs 2098497945 @default.
• W2098497945 citedByCount "5" @default.
• W2098497945 countsByYear W20984979452012 @default.
• W2098497945 countsByYear W20984979452014 @default.
• W2098497945 countsByYear W20984979452015 @default.
• W2098497945 countsByYear W20984979452018 @default.
• W2098497945 crossrefType "journal-article" @default.
• W2098497945 hasAuthorship W2098497945A5008280608 @default.
• W2098497945 hasAuthorship W2098497945A5008390320 @default.
• W2098497945 hasAuthorship W2098497945A5014662537 @default.
• W2098497945 hasAuthorship W2098497945A5030659566 @default.
• W2098497945 hasAuthorship W2098497945A5040176184 @default.
• W2098497945 hasAuthorship W2098497945A5044131502 @default.
• W2098497945 hasAuthorship W2098497945A5056788729 @default.
• W2098497945 hasAuthorship W2098497945A5084581495 @default.
• W2098497945 hasBestOaLocation W20984979451 @default.
• W2098497945 hasConcept C103278499 @default.
• W2098497945 hasConcept C103637391 @default.
• W2098497945 hasConcept C111472728 @default.
• W2098497945 hasConcept C115961682 @default.
• W2098497945 hasConcept C138885662 @default.
• W2098497945 hasConcept C154945302 @default.
• W2098497945 hasConcept C2780035454 @default.
• W2098497945 hasConcept C41008148 @default.
• W2098497945 hasConcept C60644358 @default.
• W2098497945 hasConcept C64903051 @default.
• W2098497945 hasConcept C70721500 @default.
• W2098497945 hasConcept C74187038 @default.
• W2098497945 hasConcept C86380466 @default.

• next