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• W2098511103 abstract "Introduction Only one study has evaluated Ki-67 as a predictor of the response to somatostatin analog therapy in acromegaly; however, other predictors like somatostatin receptor type 2 (SSTR2) and cytokeratin pattern expressions were not considered. Objective To evaluate whether Ki-67 is a predictor of octreotide LAR (OCT-LAR) response in somatotropinomas independent of SSTR2 and cytokeratin expression patterns. Methods Protein expression was analyzed by immunohistochemistry. The percentage of cell nuclei that were immunolabeled for Ki-67 and the percentage of cells with positive SSTR2 staining were calculated. SSTR2 expression was considered high when ≥25%, and a cutoff of 2.3% was designated for Ki-67. Tumors were classified as densely or sparsely granulated according to the cytokeratin pattern. Results Thirty-one somatotropinomas were studied. Fourteen patients (45.2%) were controlled with OCT-LAR therapy. The median Ki-67 labeling index (LI) was higher in patients not controlled with OCT-LAR than in those controlled (1.63 and 0.15 respectively, P =0.002). Higher SSTR2 expression and densely granulated tumors were correlated with control as well ( P =0.04 and 0.038 respectively). There was no difference in Ki-67 levels between patients with high and low SSTR2 expression ( P =0.651). After multivariate analysis, both Ki-67 and SSTR2 remained statistically significant as predictors of OCT-LAR response ( P =0.017 and 0.012 respectively). The Ki-67 LI was higher in sparsely than in densely granulated tumors ( P =0.047). Conclusions Ki-67 is a predictor of response to OCT-LAR in acromegaly, independent of SSTR2 expression and relates to cytokeratin patterns." @default.
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• W2098511103 date "2013-08-01" @default.
• W2098511103 modified "2023-10-18" @default.
• W2098511103 title "Ki-67 is a predictor of acromegaly control with octreotide LAR independent of SSTR2 status and relates to cytokeratin pattern" @default.
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• W2098511103 doi "https://doi.org/10.1530/eje-13-0349" @default.
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