Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098519278> ?p ?o ?g. }
- W2098519278 endingPage "2937" @default.
- W2098519278 startingPage "2931" @default.
- W2098519278 abstract "ABSTRACT Shiga toxin-producing Escherichia coli O157:H7 (STEC) is by far the most prevalent serotype associated with hemolytic uremic syndrome (HUS) although many non-O157 STEC strains have been also isolated from patients with HUS. The main virulence factor of STEC is the Shiga toxin type 2 (Stx2) present in O157 and non-O157 strains. Recently, another toxin, named subtilase cytotoxin (SubAB), has been isolated from several non-O157 strains and may contribute to the pathogenesis of HUS. Here, we have demonstrated that an O113:H21 STEC strain expressing SubAB and Stx2 inhibits normal water absorption across human colon and causes damage to the surface epithelium, necrosis, mononuclear inflammatory infiltration, edema, and marked mucin depletion. This damage was less marked, but nevertheless significant, when purified SubAB or E. coli O113:H21 expressing only SubAB was assayed. This is the first study showing that SubAB may directly participate in the mechanisms of diarrhea in children infected with non-O157 STEC strains." @default.
- W2098519278 created "2016-06-24" @default.
- W2098519278 creator A5004812972 @default.
- W2098519278 creator A5026067574 @default.
- W2098519278 creator A5038494526 @default.
- W2098519278 creator A5050006956 @default.
- W2098519278 creator A5055597053 @default.
- W2098519278 creator A5074379148 @default.
- W2098519278 date "2013-06-03" @default.
- W2098519278 modified "2023-10-18" @default.
- W2098519278 title "Inhibition of Water Absorption and Selective Damage to Human Colonic Mucosa Are Induced by Subtilase Cytotoxin Produced by Escherichia coli O113:H21" @default.
- W2098519278 cites W1904815041 @default.
- W2098519278 cites W1964853082 @default.
- W2098519278 cites W1982478214 @default.
- W2098519278 cites W2007755151 @default.
- W2098519278 cites W2019599641 @default.
- W2098519278 cites W2022268950 @default.
- W2098519278 cites W2038603974 @default.
- W2098519278 cites W2043476221 @default.
- W2098519278 cites W2055338783 @default.
- W2098519278 cites W2061480106 @default.
- W2098519278 cites W2070975617 @default.
- W2098519278 cites W2073304789 @default.
- W2098519278 cites W2088411900 @default.
- W2098519278 cites W2098500976 @default.
- W2098519278 cites W2115177266 @default.
- W2098519278 cites W2117614106 @default.
- W2098519278 cites W2123994723 @default.
- W2098519278 cites W2129058679 @default.
- W2098519278 cites W2129575453 @default.
- W2098519278 cites W2136482421 @default.
- W2098519278 cites W2144603992 @default.
- W2098519278 cites W2146297863 @default.
- W2098519278 cites W2156931773 @default.
- W2098519278 cites W2448067 @default.
- W2098519278 doi "https://doi.org/10.1128/iai.00287-13" @default.
- W2098519278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3719589" @default.
- W2098519278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23732168" @default.
- W2098519278 hasPublicationYear "2013" @default.
- W2098519278 type Work @default.
- W2098519278 sameAs 2098519278 @default.
- W2098519278 citedByCount "17" @default.
- W2098519278 countsByYear W20985192782013 @default.
- W2098519278 countsByYear W20985192782014 @default.
- W2098519278 countsByYear W20985192782015 @default.
- W2098519278 countsByYear W20985192782016 @default.
- W2098519278 countsByYear W20985192782017 @default.
- W2098519278 countsByYear W20985192782018 @default.
- W2098519278 countsByYear W20985192782019 @default.
- W2098519278 countsByYear W20985192782021 @default.
- W2098519278 countsByYear W20985192782022 @default.
- W2098519278 crossrefType "journal-article" @default.
- W2098519278 hasAuthorship W2098519278A5004812972 @default.
- W2098519278 hasAuthorship W2098519278A5026067574 @default.
- W2098519278 hasAuthorship W2098519278A5038494526 @default.
- W2098519278 hasAuthorship W2098519278A5050006956 @default.
- W2098519278 hasAuthorship W2098519278A5055597053 @default.
- W2098519278 hasAuthorship W2098519278A5074379148 @default.
- W2098519278 hasBestOaLocation W20985192781 @default.
- W2098519278 hasConcept C10389963 @default.
- W2098519278 hasConcept C104317684 @default.
- W2098519278 hasConcept C126322002 @default.
- W2098519278 hasConcept C142724271 @default.
- W2098519278 hasConcept C159047783 @default.
- W2098519278 hasConcept C203014093 @default.
- W2098519278 hasConcept C2777367657 @default.
- W2098519278 hasConcept C2778411228 @default.
- W2098519278 hasConcept C2779802037 @default.
- W2098519278 hasConcept C2780942790 @default.
- W2098519278 hasConcept C2781001907 @default.
- W2098519278 hasConcept C2781090273 @default.
- W2098519278 hasConcept C2910478007 @default.
- W2098519278 hasConcept C3019368612 @default.
- W2098519278 hasConcept C547475151 @default.
- W2098519278 hasConcept C55493867 @default.
- W2098519278 hasConcept C60987743 @default.
- W2098519278 hasConcept C61716771 @default.
- W2098519278 hasConcept C66999527 @default.
- W2098519278 hasConcept C71924100 @default.
- W2098519278 hasConcept C86803240 @default.
- W2098519278 hasConcept C89423630 @default.
- W2098519278 hasConceptScore W2098519278C10389963 @default.
- W2098519278 hasConceptScore W2098519278C104317684 @default.
- W2098519278 hasConceptScore W2098519278C126322002 @default.
- W2098519278 hasConceptScore W2098519278C142724271 @default.
- W2098519278 hasConceptScore W2098519278C159047783 @default.
- W2098519278 hasConceptScore W2098519278C203014093 @default.
- W2098519278 hasConceptScore W2098519278C2777367657 @default.
- W2098519278 hasConceptScore W2098519278C2778411228 @default.
- W2098519278 hasConceptScore W2098519278C2779802037 @default.
- W2098519278 hasConceptScore W2098519278C2780942790 @default.
- W2098519278 hasConceptScore W2098519278C2781001907 @default.
- W2098519278 hasConceptScore W2098519278C2781090273 @default.
- W2098519278 hasConceptScore W2098519278C2910478007 @default.
- W2098519278 hasConceptScore W2098519278C3019368612 @default.
- W2098519278 hasConceptScore W2098519278C547475151 @default.
- W2098519278 hasConceptScore W2098519278C55493867 @default.
- W2098519278 hasConceptScore W2098519278C60987743 @default.