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• W2098536002 abstract "Microglial cells have been shown to express carbonic anhydrase. Using carbonic anhydrase histochemistry and immunohistochemistry, different types of cen-tral nervous system microglial cells were detected, which expressed two main carbonic anhydrase (CA) isozymes during the early postnatal stage of development and after peripheral nerve injury in the spinal cord of adult rats. Amoeboid and reactive microglial cells were heavily immunostained for CA-II and CA-III and showed colocalization with complement receptor type 3 and Griffonia Simplicifolia B4 isolectin. Resting microglial cells in the brain and spinal cord showed faint CA-III staining and were negative for CA-II. These results show that not only CA-II, but also CA-III isozyme is represented in the central nervous system and carbonic anhydrase activity may correlate with metabolic and immunological changes of microglial cells. These data also further strengthen the idea of the mesodermal origin of central nervous system macrophages. © 1993 Wiley-Liss, Inc." @default.
• W2098536002 created "2016-06-24" @default.
• W2098536002 creator A5069028643 @default.
• W2098536002 date "1993-06-01" @default.
• W2098536002 modified "2023-09-26" @default.
• W2098536002 title "Differential expression of carbonic anhydrase isozymes in microglial cell types" @default.
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• W2098536002 doi "https://doi.org/10.1002/glia.440080209" @default.
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• W2098536002 hasPublicationYear "1993" @default.
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