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- W2098538086 abstract "Although the Man-6-P-independent lysosomal sorting of prosaposin, a precursor of four saposins (A, B, C, and D) is not understood, a protein/lipid interaction is considered. Immunocytochemical analysis revealed that each single saposin linked to the C-terminus of prosaposin and to secretory albumin, drives the chimeric protein to lysosomes in COS-7 cells. Quantitative image analysis demonstrated that saposins are targeted with different efficiency (P<0.05) and in a less smooth manner than the precursor. Despite a very close homology, the charge distribution at the surface of 3D comparative models between saposins appeared different. Western blotting monitored prosaposin in cells also as a di- or trimeric form, whereas the chimeric saposins as monomeric. This implies that each amphipathic saposin-like motif may be a part of the overall structural requirements for binding of the precursor to the membrane lipids of transport vesicle. The crystal structure of saposin B demonstrating two dimeric units for lipid binding supports current findings." @default.
- W2098538086 created "2016-06-24" @default.
- W2098538086 creator A5063110372 @default.
- W2098538086 date "2003-08-01" @default.
- W2098538086 modified "2023-10-17" @default.
- W2098538086 title "Structural requirements for lysosomal targeting of the prosaposin precursor protein" @default.
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- W2098538086 doi "https://doi.org/10.1016/s1065-6995(03)00124-0" @default.
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