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- W2098541347 endingPage "101" @default.
- W2098541347 startingPage "91" @default.
- W2098541347 abstract "Diabetes mellitus is a disorder of glucose homeostasis that affects more than 24 million Americans and 382 million individuals worldwide. Dysregulated insulin secretion from the pancreatic β cells plays a central role in the pathophysiology of all forms of diabetes mellitus. Therefore, an enhanced understanding of the pathways that contribute to β-cell failure is imperative. Epigenetics refers to heritable changes in DNA transcription that occur in the absence of changes to the linear DNA nucleotide sequence. Recent evidence suggests an expanding role of the β-cell epigenome in the regulation of metabolic health. The goal of this review is to discuss maladaptive changes in β-cell DNA methylation patterns and chromatin architecture, and their contribution to diabetes pathophysiology. Efforts to modulate the β-cell epigenome as a means to prevent, diagnose, and treat diabetes are also discussed." @default.
- W2098541347 created "2016-06-24" @default.
- W2098541347 creator A5026442384 @default.
- W2098541347 creator A5063131669 @default.
- W2098541347 date "2015-01-01" @default.
- W2098541347 modified "2023-09-26" @default.
- W2098541347 title "Translational implications of the β-cell epigenome in diabetes mellitus" @default.
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