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• W2098558997 abstract "This investigation showed that phagocytosis of virulent Salmonella typhimurium by promonocytic leukemia cell line U1, which contains human immunodeficiency virus type 1 (HIV-1) provirus but produces minimal or no virus, and not by uninfected U937 cell line resulted in expression of a functional P glycoprotein. Anti-tumor necrosis factor-alpha (TNF alpha) monoclonal antibody failed to inhibit S. typhimurium-induced P glycoprotein expression. Furthermore, recombinant TNF alpha had no effect on the induction of P glycoprotein expression in U1 cells. These data demonstrate that phagocytosis of virulent S. typhimurium results in an induction of P glycoprotein in association with HIV-1 infection; however, TNF alpha does not appear to play a significant role. Thus, secondary microbial infection in HIV-1-positive persons may play a role in multidrug resistance against antiviral and other antimicrobial agents by an induction of P glycoprotein." @default.
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• W2098558997 date "1994-04-01" @default.
• W2098558997 modified "2023-09-25" @default.
• W2098558997 title "Salmonella typhimurium Induces Expression of P Glycoprotein (Multidrug Resistance 1 Gene Product) in a Promonocytic Cell Line Chronically Infected with Human Immunodeficiency Virus Type 1" @default.
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• W2098558997 doi "https://doi.org/10.1093/infdis/169.4.760" @default.
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