Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098573045> ?p ?o ?g. }
- W2098573045 endingPage "743" @default.
- W2098573045 startingPage "733" @default.
- W2098573045 abstract "We provide evidence that a class of integrins combines with the adaptor Shc and thereby with Grb2. Coimmunoprecipitation and mutagenesis experiments indicate that the recruitment of Shc is specified by the extracellular or transmembrane domain of integrin α subunit and suggest that this process is mediated by caveolin. Mutagenesis and dominant-negative inhibition studies reveal that Shc is necessary and sufficient for activation of the MAP kinase pathway in response to integrin ligation. Mitogens and Shc-activating integrins cooperate to promote transcription from the Fos serum response element and transit through G1. In contrast, adhesion mediated by integrins not linked to Shc results in cell cycle arrest and apoptosis even in presence of mitogens. These findings indicate that the association of specific integrins with Shc regulates cell survival and cell cycle progression." @default.
- W2098573045 created "2016-06-24" @default.
- W2098573045 creator A5003417891 @default.
- W2098573045 creator A5021766049 @default.
- W2098573045 creator A5024937751 @default.
- W2098573045 creator A5049475794 @default.
- W2098573045 creator A5070827614 @default.
- W2098573045 date "1996-11-01" @default.
- W2098573045 modified "2023-10-17" @default.
- W2098573045 title "The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression" @default.
- W2098573045 cites W1532442718 @default.
- W2098573045 cites W1603788311 @default.
- W2098573045 cites W1834622832 @default.
- W2098573045 cites W1849793110 @default.
- W2098573045 cites W188222869 @default.
- W2098573045 cites W1919179089 @default.
- W2098573045 cites W1948774306 @default.
- W2098573045 cites W1976385326 @default.
- W2098573045 cites W1976655304 @default.
- W2098573045 cites W1981462495 @default.
- W2098573045 cites W1982186905 @default.
- W2098573045 cites W1983072511 @default.
- W2098573045 cites W1986758681 @default.
- W2098573045 cites W1987270140 @default.
- W2098573045 cites W1989480480 @default.
- W2098573045 cites W1989780564 @default.
- W2098573045 cites W1993803695 @default.
- W2098573045 cites W1996910230 @default.
- W2098573045 cites W1997121235 @default.
- W2098573045 cites W2001753204 @default.
- W2098573045 cites W2009484032 @default.
- W2098573045 cites W2011497948 @default.
- W2098573045 cites W2012799785 @default.
- W2098573045 cites W2028691987 @default.
- W2098573045 cites W2029231027 @default.
- W2098573045 cites W2035641694 @default.
- W2098573045 cites W2044806537 @default.
- W2098573045 cites W2051541258 @default.
- W2098573045 cites W2054779757 @default.
- W2098573045 cites W2059442542 @default.
- W2098573045 cites W2061207312 @default.
- W2098573045 cites W2066367871 @default.
- W2098573045 cites W2074713306 @default.
- W2098573045 cites W2075505332 @default.
- W2098573045 cites W2076590551 @default.
- W2098573045 cites W2098619103 @default.
- W2098573045 cites W2099890567 @default.
- W2098573045 cites W2102598791 @default.
- W2098573045 cites W2114463465 @default.
- W2098573045 cites W2135057126 @default.
- W2098573045 cites W2154169742 @default.
- W2098573045 cites W2166578267 @default.
- W2098573045 cites W2221871923 @default.
- W2098573045 cites W4232671899 @default.
- W2098573045 cites W4246253484 @default.
- W2098573045 cites W4251554787 @default.
- W2098573045 cites W4361868961 @default.
- W2098573045 doi "https://doi.org/10.1016/s0092-8674(00)81392-6" @default.
- W2098573045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8929541" @default.
- W2098573045 hasPublicationYear "1996" @default.
- W2098573045 type Work @default.
- W2098573045 sameAs 2098573045 @default.
- W2098573045 citedByCount "714" @default.
- W2098573045 countsByYear W20985730452012 @default.
- W2098573045 countsByYear W20985730452013 @default.
- W2098573045 countsByYear W20985730452014 @default.
- W2098573045 countsByYear W20985730452015 @default.
- W2098573045 countsByYear W20985730452016 @default.
- W2098573045 countsByYear W20985730452017 @default.
- W2098573045 countsByYear W20985730452018 @default.
- W2098573045 countsByYear W20985730452019 @default.
- W2098573045 countsByYear W20985730452020 @default.
- W2098573045 countsByYear W20985730452021 @default.
- W2098573045 countsByYear W20985730452022 @default.
- W2098573045 countsByYear W20985730452023 @default.
- W2098573045 crossrefType "journal-article" @default.
- W2098573045 hasAuthorship W2098573045A5003417891 @default.
- W2098573045 hasAuthorship W2098573045A5021766049 @default.
- W2098573045 hasAuthorship W2098573045A5024937751 @default.
- W2098573045 hasAuthorship W2098573045A5049475794 @default.
- W2098573045 hasAuthorship W2098573045A5070827614 @default.
- W2098573045 hasBestOaLocation W20985730451 @default.
- W2098573045 hasConcept C104317684 @default.
- W2098573045 hasConcept C131312102 @default.
- W2098573045 hasConcept C134459356 @default.
- W2098573045 hasConcept C1491633281 @default.
- W2098573045 hasConcept C183786373 @default.
- W2098573045 hasConcept C195687474 @default.
- W2098573045 hasConcept C25602115 @default.
- W2098573045 hasConcept C29537977 @default.
- W2098573045 hasConcept C55493867 @default.
- W2098573045 hasConcept C62478195 @default.
- W2098573045 hasConcept C85789140 @default.
- W2098573045 hasConcept C86803240 @default.
- W2098573045 hasConcept C95444343 @default.
- W2098573045 hasConceptScore W2098573045C104317684 @default.
- W2098573045 hasConceptScore W2098573045C131312102 @default.
- W2098573045 hasConceptScore W2098573045C134459356 @default.