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• W2098575615 abstract "Age-related macular degeneration (AMD) is a complex disorder that is responsible for the majority of central vision loss in older adults living in developed countries. Phenotypic and genetic heterogeneity complicate the analysis of genome-wide scans for AMD susceptibility loci. The ordered subset analysis (OSA) method is an approach for reducing heterogeneity, increasing statistical power for detecting linkage, and helping to define the most informative data set for follow-up analysis. OSA assesses the linkage evidence in subsets of potentially more homogeneous families by rank-ordering family-specific lod scores with respect to trait-associated covariates or phenotypic features. Here, we present results of incorporating five continuous covariates into our genome-wide linkage analysis of 389 microsatellite markers in 62 multiplex families: Body mass index (BMI), systolic (SBP) and diastolic (DBP) blood pressure, intraocular pressure (IOP), and pack-years of cigarette smoking. Chromosome-wide significance of increases in nonparametric multipoint lod scores in covariate-defined subsets relative to the overall sample was assessed by permutation.Using a correction for testing multiple covariates, statistically significant lod score increases were observed for two chromosomal regions: 14q13 with a lod score of 3.2 in 28 families with average IOP </= 15.5 (p = 0.002), and 6q14 with a lod score of 1.6 in eight families with average BMI >/= 30.1 (p = 0.0004). On chromosome 16p12, nominally significant lod score increases (p </= 0.05), up to a lod score of 2.9 in 32 families, were observed with several covariate orderings. While less significant, this was the only region where linkage evidence was associated with multiple clinically meaningful covariates and the only nominally significant finding when analysis was restricted to advanced forms of AMD. Families with linkage to 16p12 had higher averages of SBP, IOP and BMI and were primarily affected with neovascular AMD. For all three regions, linkage signals at or very near the peak marker have previously been reported.Our results suggest that a susceptibility gene on chromosome 16p12 may predispose to AMD, particularly to the neovascular form, and that further research into the previously suggested association of neovascular AMD and systemic hypertension is warranted." @default.
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• W2098575615 date "2004-01-01" @default.
• W2098575615 modified "2023-10-16" @default.
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• W2098575615 cites W1517723833 @default.
• W2098575615 cites W1525112357 @default.
• W2098575615 cites W1543801259 @default.
• W2098575615 cites W1560237148 @default.
• W2098575615 cites W1565600091 @default.
• W2098575615 cites W1573040585 @default.
• W2098575615 cites W1641197739 @default.
• W2098575615 cites W16466320 @default.
• W2098575615 cites W1740303948 @default.
• W2098575615 cites W180812339 @default.
• W2098575615 cites W1809957428 @default.
• W2098575615 cites W1964511379 @default.
• W2098575615 cites W1967024894 @default.
• W2098575615 cites W1967253078 @default.
• W2098575615 cites W1967749499 @default.
• W2098575615 cites W1968012352 @default.
• W2098575615 cites W1968744211 @default.
• W2098575615 cites W1972731291 @default.
• W2098575615 cites W1986289289 @default.
• W2098575615 cites W1997616950 @default.
• W2098575615 cites W2005511088 @default.
• W2098575615 cites W2009699156 @default.
• W2098575615 cites W2021045531 @default.
• W2098575615 cites W2024729125 @default.
• W2098575615 cites W2025176768 @default.
• W2098575615 cites W2039519120 @default.
• W2098575615 cites W2041625092 @default.
• W2098575615 cites W2041746316 @default.
• W2098575615 cites W2042335805 @default.
• W2098575615 cites W2043247687 @default.
• W2098575615 cites W2044425793 @default.
• W2098575615 cites W2047282046 @default.
• W2098575615 cites W2052476475 @default.
• W2098575615 cites W2060170269 @default.
• W2098575615 cites W2063426414 @default.
• W2098575615 cites W2063763497 @default.
• W2098575615 cites W2069110097 @default.
• W2098575615 cites W2071120499 @default.
• W2098575615 cites W2072038834 @default.
• W2098575615 cites W2079224328 @default.
• W2098575615 cites W2084190964 @default.
• W2098575615 cites W2088708872 @default.
• W2098575615 cites W2094082523 @default.
• W2098575615 cites W2095956755 @default.
• W2098575615 cites W2096201017 @default.
• W2098575615 cites W2099752477 @default.
• W2098575615 cites W2116163760 @default.
• W2098575615 cites W2117696490 @default.
• W2098575615 cites W2119486327 @default.
• W2098575615 cites W2120110441 @default.
• W2098575615 cites W2120246214 @default.
• W2098575615 cites W2120590773 @default.
• W2098575615 cites W2121286926 @default.
• W2098575615 cites W2129572698 @default.
• W2098575615 cites W2130683634 @default.
• W2098575615 cites W2133598188 @default.
• W2098575615 cites W2136525843 @default.
• W2098575615 cites W2137015106 @default.
• W2098575615 cites W2137330273 @default.
• W2098575615 cites W2137792435 @default.
• W2098575615 cites W2144588016 @default.
• W2098575615 cites W2152909798 @default.
• W2098575615 cites W2156121263 @default.
• W2098575615 cites W2158220198 @default.
• W2098575615 cites W2158770960 @default.
• W2098575615 cites W2170008072 @default.
• W2098575615 cites W2170009526 @default.
• W2098575615 cites W2331955235 @default.
• W2098575615 cites W2411273799 @default.
• W2098575615 cites W2566154985 @default.
• W2098575615 cites W4248715188 @default.
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• W2098575615 doi "https://doi.org/10.1186/1471-2156-5-18" @default.
• W2098575615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/481059" @default.
• W2098575615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15238159" @default.
• W2098575615 hasPublicationYear "2004" @default.
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