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• W2098591117 abstract "Histone deacetylase inhibitor valproic acid (VPA) was recently shown to enhance proliferation and self-renewal of normal hematopoietic stem cells, raising the possibility that VPA may also support growth of leukemic progenitor cells (LPC). Here, VPA maintains a significantly higher proportion of CD34+ LPC and colony forming units compared to control cultures in six AML samples, but selectively reduces leukemic cell numbers in another AML sample with expression of AML1/ETO. Our data suggest a differential effect of VPA on the small population of AML progenitor cells and the bulk of aberrantly differentiated blasts in the majority of AML samples tested." @default.
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• W2098591117 date "2007-04-01" @default.
• W2098591117 modified "2023-10-12" @default.
• W2098591117 title "Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia" @default.
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• W2098591117 doi "https://doi.org/10.3324/haematol.10758" @default.
• W2098591117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17488665" @default.
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