Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098600025> ?p ?o ?g. }
- W2098600025 endingPage "603" @default.
- W2098600025 startingPage "601" @default.
- W2098600025 abstract "We describe the effect of interleukin 6 (IL-6) blockade using tocilizumab (TCZ) for inducing and maintaining remission of refractory polyarteritis nodosa (PAN). Three patients with refractory PAN defined according to the American College of Rheumatology criteria were treated with TCZ infusions (8 mg/kg) on a monthly basis. All of them had severe cutaneous and articular involvement with elevated biological inflammatory markers. One suffered from a neuritis multiplex and one from renal and digestive damage. All three patients were dependent on high doses of glucocorticoids (above 0.5 mg/kg) and two of them were resistant to immunosuppressive drugs. All patients achieved and maintained clinical response and normalisation of the inflammation acute-phase proteins after a few weeks of treatment with TCZ. Prednisolone could be reduced by an average of 41–13 mg/day. These first case reports suggest that IL-6 blockade using TCZ could be a therapeutic alternative to induce remission in patients with polyarteritis nodosa resistant or intolerant to the reference treatment." @default.
- W2098600025 created "2016-06-24" @default.
- W2098600025 creator A5044385376 @default.
- W2098600025 creator A5085770662 @default.
- W2098600025 date "2012-03-13" @default.
- W2098600025 modified "2023-10-17" @default.
- W2098600025 title "Gene of the month: PTEN" @default.
- W2098600025 cites W1964948442 @default.
- W2098600025 cites W1969166125 @default.
- W2098600025 cites W1973577899 @default.
- W2098600025 cites W1976314401 @default.
- W2098600025 cites W1977416006 @default.
- W2098600025 cites W1984252209 @default.
- W2098600025 cites W1984621921 @default.
- W2098600025 cites W1988769784 @default.
- W2098600025 cites W1992051089 @default.
- W2098600025 cites W2001853125 @default.
- W2098600025 cites W2009886463 @default.
- W2098600025 cites W2012410089 @default.
- W2098600025 cites W2020416725 @default.
- W2098600025 cites W2025319925 @default.
- W2098600025 cites W2033783187 @default.
- W2098600025 cites W2043806397 @default.
- W2098600025 cites W2050818286 @default.
- W2098600025 cites W2058733098 @default.
- W2098600025 cites W2059411043 @default.
- W2098600025 cites W2060001443 @default.
- W2098600025 cites W2060387248 @default.
- W2098600025 cites W2068345721 @default.
- W2098600025 cites W2070732456 @default.
- W2098600025 cites W2070805824 @default.
- W2098600025 cites W2075920859 @default.
- W2098600025 cites W2077582389 @default.
- W2098600025 cites W2087843790 @default.
- W2098600025 cites W2095659495 @default.
- W2098600025 cites W2099658407 @default.
- W2098600025 cites W2102648794 @default.
- W2098600025 cites W2111062014 @default.
- W2098600025 cites W2113190292 @default.
- W2098600025 cites W2114725617 @default.
- W2098600025 cites W2125163614 @default.
- W2098600025 cites W2125543544 @default.
- W2098600025 cites W2128613144 @default.
- W2098600025 cites W2135838271 @default.
- W2098600025 cites W2136602069 @default.
- W2098600025 cites W2140154966 @default.
- W2098600025 cites W2150233389 @default.
- W2098600025 cites W2152654745 @default.
- W2098600025 cites W2155737059 @default.
- W2098600025 cites W2160700807 @default.
- W2098600025 cites W2161810908 @default.
- W2098600025 cites W2170296344 @default.
- W2098600025 cites W2312585383 @default.
- W2098600025 cites W4255080289 @default.
- W2098600025 doi "https://doi.org/10.1136/jclinpath-2012-200711" @default.
- W2098600025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22416141" @default.
- W2098600025 hasPublicationYear "2012" @default.
- W2098600025 type Work @default.
- W2098600025 sameAs 2098600025 @default.
- W2098600025 citedByCount "14" @default.
- W2098600025 countsByYear W20986000252013 @default.
- W2098600025 countsByYear W20986000252014 @default.
- W2098600025 countsByYear W20986000252015 @default.
- W2098600025 countsByYear W20986000252018 @default.
- W2098600025 countsByYear W20986000252019 @default.
- W2098600025 countsByYear W20986000252021 @default.
- W2098600025 countsByYear W20986000252022 @default.
- W2098600025 crossrefType "journal-article" @default.
- W2098600025 hasAuthorship W2098600025A5044385376 @default.
- W2098600025 hasAuthorship W2098600025A5085770662 @default.
- W2098600025 hasConcept C121332964 @default.
- W2098600025 hasConcept C126322002 @default.
- W2098600025 hasConcept C142424586 @default.
- W2098600025 hasConcept C170493617 @default.
- W2098600025 hasConcept C198451711 @default.
- W2098600025 hasConcept C2776715498 @default.
- W2098600025 hasConcept C2776914184 @default.
- W2098600025 hasConcept C2777178219 @default.
- W2098600025 hasConcept C2777575956 @default.
- W2098600025 hasConcept C2778468042 @default.
- W2098600025 hasConcept C2781059491 @default.
- W2098600025 hasConcept C71924100 @default.
- W2098600025 hasConcept C87355193 @default.
- W2098600025 hasConcept C90924648 @default.
- W2098600025 hasConceptScore W2098600025C121332964 @default.
- W2098600025 hasConceptScore W2098600025C126322002 @default.
- W2098600025 hasConceptScore W2098600025C142424586 @default.
- W2098600025 hasConceptScore W2098600025C170493617 @default.
- W2098600025 hasConceptScore W2098600025C198451711 @default.
- W2098600025 hasConceptScore W2098600025C2776715498 @default.
- W2098600025 hasConceptScore W2098600025C2776914184 @default.
- W2098600025 hasConceptScore W2098600025C2777178219 @default.
- W2098600025 hasConceptScore W2098600025C2777575956 @default.
- W2098600025 hasConceptScore W2098600025C2778468042 @default.
- W2098600025 hasConceptScore W2098600025C2781059491 @default.
- W2098600025 hasConceptScore W2098600025C71924100 @default.
- W2098600025 hasConceptScore W2098600025C87355193 @default.
- W2098600025 hasConceptScore W2098600025C90924648 @default.