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• W2098609916 endingPage "533" @default.
• W2098609916 startingPage "521" @default.
• W2098609916 abstract "Receptors for the Fc portion of immunoglobulin molecules (FcR) present on leukocyte cell membranes mediate a large number of cellular responses that are very important in host defense. Cross-linking of FcR by immune complexes leads to functions such as phagocytosis, cell cytotoxicity, production and secretion of inflammatory mediators, and modulation of the immune response. Molecular characterization of FcRs indicates the existence of several types of these receptors, which seem to be redundant in their cell distribution and function. There is a great deal of interest in understanding how these various receptors signal the cell to respond in different ways during inflammation and the immune response. Previous studies indicate that FcR signaling shares elements with the T and B cell antigen receptors. Signaling is initiated in all of them by activation of tyrosine kinases of the Src and ZAP-70 families. Subsequent events, which vary depending on the cell type and receptor involved, include activation of other enzymes such as phospholipase Cgamma1, phosphatidylinositol-3-kinase, and mitogen-activated protein kinase. Several recent lines of research, including studies of phagocytosis by FcR-transfected cells, antibody-dependent cytotoxicity by natural killer cells, mast cell degranulation, and FcR-deficient mice, have given us new insights on the signal transduction pathways activated by FcRs. This review describes the advances in these areas and presents a general model for FcR-mediated signaling." @default.
• W2098609916 created "2016-06-24" @default.
• W2098609916 creator A5011310707 @default.
• W2098609916 creator A5090667961 @default.
• W2098609916 date "1998-05-01" @default.
• W2098609916 modified "2023-10-13" @default.
• W2098609916 title "Signal transduction by immunoglobulin Fc receptors" @default.
• W2098609916 cites W147011734 @default.
• W2098609916 cites W1481629090 @default.
• W2098609916 cites W1499222468 @default.
• W2098609916 cites W1501693497 @default.
• W2098609916 cites W1505084152 @default.
• W2098609916 cites W1510771719 @default.
• W2098609916 cites W1512594812 @default.
• W2098609916 cites W1512909384 @default.
• W2098609916 cites W1527081333 @default.
• W2098609916 cites W1530177683 @default.
• W2098609916 cites W1530340727 @default.
• W2098609916 cites W1530970237 @default.
• W2098609916 cites W1533457677 @default.
• W2098609916 cites W1543778012 @default.
• W2098609916 cites W1556867369 @default.
• W2098609916 cites W1558539262 @default.
• W2098609916 cites W1562912280 @default.
• W2098609916 cites W1563419652 @default.
• W2098609916 cites W1564011208 @default.
• W2098609916 cites W1564132479 @default.
• W2098609916 cites W1565477787 @default.
• W2098609916 cites W1578284751 @default.
• W2098609916 cites W1589012667 @default.
• W2098609916 cites W1589063951 @default.
• W2098609916 cites W1598201397 @default.
• W2098609916 cites W1599737023 @default.
• W2098609916 cites W1605822460 @default.
• W2098609916 cites W1613312511 @default.
• W2098609916 cites W1618519163 @default.
• W2098609916 cites W1632086955 @default.
• W2098609916 cites W165036993 @default.
• W2098609916 cites W1670289781 @default.
• W2098609916 cites W1704017123 @default.
• W2098609916 cites W1793546710 @default.
• W2098609916 cites W1861660397 @default.
• W2098609916 cites W1878715199 @default.
• W2098609916 cites W1908102564 @default.
• W2098609916 cites W1928375268 @default.
• W2098609916 cites W1928679615 @default.
• W2098609916 cites W1942232004 @default.
• W2098609916 cites W1955623114 @default.
• W2098609916 cites W1966286149 @default.
• W2098609916 cites W1968585354 @default.
• W2098609916 cites W1972443545 @default.
• W2098609916 cites W1974555059 @default.
• W2098609916 cites W1976805459 @default.
• W2098609916 cites W1980166477 @default.
• W2098609916 cites W1981563612 @default.
• W2098609916 cites W1983940041 @default.
• W2098609916 cites W1983960385 @default.
• W2098609916 cites W1985866176 @default.
• W2098609916 cites W1990173454 @default.
• W2098609916 cites W1992605956 @default.
• W2098609916 cites W1994586690 @default.
• W2098609916 cites W1996441373 @default.
• W2098609916 cites W1997634231 @default.
• W2098609916 cites W2000061036 @default.
• W2098609916 cites W2007163229 @default.
• W2098609916 cites W2007745785 @default.
• W2098609916 cites W2007949618 @default.
• W2098609916 cites W2012177306 @default.
• W2098609916 cites W2015366690 @default.
• W2098609916 cites W2017037387 @default.
• W2098609916 cites W2018313573 @default.
• W2098609916 cites W2018826402 @default.
• W2098609916 cites W2020397881 @default.
• W2098609916 cites W2021757024 @default.
• W2098609916 cites W2021993298 @default.
• W2098609916 cites W2026021648 @default.
• W2098609916 cites W2028593992 @default.
• W2098609916 cites W2028669354 @default.
• W2098609916 cites W2030788598 @default.
• W2098609916 cites W2031514258 @default.
• W2098609916 cites W2032062053 @default.
• W2098609916 cites W2035439001 @default.
• W2098609916 cites W2042043540 @default.
• W2098609916 cites W2042209841 @default.
• W2098609916 cites W2044732378 @default.
• W2098609916 cites W2044732680 @default.
• W2098609916 cites W2048359961 @default.
• W2098609916 cites W2052054743 @default.
• W2098609916 cites W2053142169 @default.
• W2098609916 cites W2055143049 @default.
• W2098609916 cites W2055444005 @default.
• W2098609916 cites W2056206771 @default.
• W2098609916 cites W2057305326 @default.
• W2098609916 cites W2057791641 @default.
• W2098609916 cites W2057887597 @default.
• W2098609916 cites W2058441584 @default.
• W2098609916 cites W2060922997 @default.
• W2098609916 cites W2061452540 @default.

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