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• W2098631245 startingPage "39" @default.
• W2098631245 abstract "Proliferation and differentiation of mammary epithelia are regulated by the combined action of systemic hormones and locally derived paracrine growth factors. Keratinocyte growth factor (KGF) is a potential candidate stromal factor that may participate in the hormonal control of stromal/epithelial interactions. In this study, we have examined the in vivo effect of 17beta-estradiol (E) treatment on KGF expression in mammary glands of peripubertal (5-week-old) and mature (11-week-old) mice. Mice received subcutaneous injections of hormone after which KGF mRNA levels were assayed by ribonuclease protection analysis of mammary gland RNA. E treatment caused a dose- and time-dependent increase in KGF mRNA levels in intact mice from both age groups. Neither 17alpha-estradiol nor progesterone injection affected KGF mRNA levels. Comparison of the relative expression of KGF in parenchyma-free fat pads and in intact glands demonstrated that the basal and E-dependent KGF mRNA levels did not require the presence of mammary epithelium. ELISA assay of KGF tissue content demonstrated that concomitantly with an up-regulation of mRNA, E treatment also increased KGF protein in mammary glands from peripubertal and mature mice. These data show that E treatment stimulates both KGF mRNA and protein expression in mammary stroma in vivo and raises the possibility that KGF has a role in E-regulated mammary gland development." @default.
• W2098631245 created "2016-06-24" @default.
• W2098631245 creator A5048443604 @default.
• W2098631245 creator A5088706447 @default.
• W2098631245 date "2000-04-01" @default.
• W2098631245 modified "2023-10-06" @default.
• W2098631245 title "Estrogen treatment in vivo increases keratinocyte growth factor expression in the mammary gland" @default.
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• W2098631245 doi "https://doi.org/10.1677/joe.0.1650039" @default.
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