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• W2098642017 abstract "Collectins are effector molecules of the innate immune system that play an important role in the first line of defence against bacteria, viruses and fungi. Most of their interactions with microorganisms are mediated through their carbohydrate recognition domain (CRD), which binds in a Ca(2+)-dependent manner to glycoconjugates. This domain is a well-known structure that is present in a larger group of proteins comprising the C-type lectin domain family. Collectins form a subgroup within this family based on the presence of a collagen domain and the trimerization of CRDs, which are essential for the ligand-binding properties of these proteins. The ligand specificity among the nine collectin members is significantly different as a result of both the structural organization of the trimers and specific sequence changes in the binding pocket of the CRD. In addition, some collectin members have additional features, such as N-linked glycosylation of CRD residues and additional loop structures within the CRD that have a large impact on their interaction with the glycoconjugates present on microorganisms or host cells. The availability of crystal structures of three members of the collectin family (surfactant proteins A and D and mannan-binding protein) provides an important tool for addressing the impact of these CRD differences on ligand binding. In this review, the structural differences and similarities between the CRDs of collectins are summarized and their relationship with their ligand-binding characteristics is discussed." @default.
• W2098642017 created "2016-06-24" @default.
• W2098642017 creator A5030530700 @default.
• W2098642017 creator A5041732138 @default.
• W2098642017 creator A5060218725 @default.
• W2098642017 date "2011-07-01" @default.
• W2098642017 modified "2023-09-30" @default.
• W2098642017 title "The carbohydrate recognition domain of collectins" @default.
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• W2098642017 doi "https://doi.org/10.1111/j.1742-4658.2011.08206.x" @default.
• W2098642017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21651725" @default.
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