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• W2098644175 startingPage "5140" @default.
• W2098644175 abstract "ABSTRACT Protein synthesis is initiated universally with the amino acid methionine. In Escherichia coli , studies with anticodon sequence mutants of the initiator methionine tRNA have shown that protein synthesis can be initiated with several other amino acids. In eukaryotic systems, however, a yeast initiator tRNA aminoacylated with isoleucine was found to be inactive in initiation in mammalian cell extracts. This finding raised the question of whether methionine is the only amino acid capable of initiation of protein synthesis in eukaryotes. In this work, we studied the activities, in initiation, of four different anticodon sequence mutants of human initiator tRNA in mammalian COS1 cells, using reporter genes carrying mutations in the initiation codon that are complementary to the tRNA anticodons. The mutant tRNAs used are aminoacylated with glutamine, methionine, and valine. Our results show that in the presence of the corresponding mutant initiator tRNAs, AGG and GUC can initiate protein synthesis in COS1 cells with methionine and valine, respectively. CAG initiates protein synthesis with glutamine but extremely poorly, whereas UAG could not be used to initiate protein synthesis with glutamine. We discuss the potential applications of the mutant initiator tRNA-dependent initiation of protein synthesis with codons other than AUG for studying the many interesting aspects of protein synthesis initiation in mammalian cells." @default.
• W2098644175 created "2016-06-24" @default.
• W2098644175 creator A5006288716 @default.
• W2098644175 creator A5076354181 @default.
• W2098644175 date "1998-09-01" @default.
• W2098644175 modified "2023-10-12" @default.
• W2098644175 title "Initiation of Protein Synthesis in Mammalian Cells with Codons Other Than AUG and Amino Acids Other Than Methionine" @default.
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• W2098644175 doi "https://doi.org/10.1128/mcb.18.9.5140" @default.
• W2098644175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/109099" @default.
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• W2098644175 hasPublicationYear "1998" @default.
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