Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098646537> ?p ?o ?g. }
- W2098646537 endingPage "4153" @default.
- W2098646537 startingPage "4144" @default.
- W2098646537 abstract "The 26S proteasome is a multisubunit protein- destroying machinery that degrades ubiquitin-tagged proteins. To date only a single species of Rpn10, which possibly functions as a multiubiquitin chain-binding subunit, has been identified in various organisms. Here we report that mouse Rpn10 mRNAs occur in at least five distinct forms, named Rpn10a to Rpn10e, and that they are generated from a single gene by developmentally regulated, alternative splicing. Rpn10a is ubiquitously expressed, whereas Rpn10e is expressed only in embryos, with the highest levels of expression in the brain. Both forms of Rpn10 are components of the 26S proteasome, with an apparently similar affinity for multiubiquitylated [(125)I]lysozyme in vitro. However, they exert markedly divergent effects on the destruction of B-type cyclin in Xenopus egg extracts. Thus, the 26S proteasome occurs in at least two functionally distinct forms: one containing a ubiquitously expressed Rpn10a and the other a newly identified, embryo-specific Rpn10e. While the former is thought to perform proteolysis constitutively in a wide variety of cells, the latter may play a specialized role in early embryonic development." @default.
- W2098646537 created "2016-06-24" @default.
- W2098646537 creator A5009824094 @default.
- W2098646537 creator A5015030223 @default.
- W2098646537 creator A5018182534 @default.
- W2098646537 creator A5018866207 @default.
- W2098646537 creator A5025748633 @default.
- W2098646537 creator A5026608718 @default.
- W2098646537 creator A5036374138 @default.
- W2098646537 creator A5072809750 @default.
- W2098646537 creator A5077483738 @default.
- W2098646537 creator A5078718906 @default.
- W2098646537 creator A5079097090 @default.
- W2098646537 creator A5086892094 @default.
- W2098646537 creator A5089532607 @default.
- W2098646537 date "2000-08-01" @default.
- W2098646537 modified "2023-10-02" @default.
- W2098646537 title "Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes" @default.
- W2098646537 cites W141648157 @default.
- W2098646537 cites W1496897161 @default.
- W2098646537 cites W1508243224 @default.
- W2098646537 cites W1515490675 @default.
- W2098646537 cites W1904980709 @default.
- W2098646537 cites W1967891453 @default.
- W2098646537 cites W1969561251 @default.
- W2098646537 cites W1976582166 @default.
- W2098646537 cites W1979119004 @default.
- W2098646537 cites W1985207677 @default.
- W2098646537 cites W1989047270 @default.
- W2098646537 cites W1991381449 @default.
- W2098646537 cites W2003836768 @default.
- W2098646537 cites W2013339424 @default.
- W2098646537 cites W2024627774 @default.
- W2098646537 cites W2025331058 @default.
- W2098646537 cites W2026632566 @default.
- W2098646537 cites W2031623763 @default.
- W2098646537 cites W2038751264 @default.
- W2098646537 cites W2040030781 @default.
- W2098646537 cites W2046502356 @default.
- W2098646537 cites W2064993319 @default.
- W2098646537 cites W2072004809 @default.
- W2098646537 cites W2078210518 @default.
- W2098646537 cites W2079223456 @default.
- W2098646537 cites W2080311153 @default.
- W2098646537 cites W2082971734 @default.
- W2098646537 cites W2083399536 @default.
- W2098646537 cites W2088825773 @default.
- W2098646537 cites W2111524632 @default.
- W2098646537 cites W2123781000 @default.
- W2098646537 cites W2144593863 @default.
- W2098646537 cites W2145216906 @default.
- W2098646537 cites W2155150958 @default.
- W2098646537 cites W2157036573 @default.
- W2098646537 cites W2160286042 @default.
- W2098646537 cites W2164710551 @default.
- W2098646537 cites W2166987747 @default.
- W2098646537 cites W2178503716 @default.
- W2098646537 cites W4245819220 @default.
- W2098646537 cites W4255738047 @default.
- W2098646537 doi "https://doi.org/10.1093/emboj/19.15.4144" @default.
- W2098646537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/306610" @default.
- W2098646537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10921894" @default.
- W2098646537 hasPublicationYear "2000" @default.
- W2098646537 type Work @default.
- W2098646537 sameAs 2098646537 @default.
- W2098646537 citedByCount "48" @default.
- W2098646537 countsByYear W20986465372012 @default.
- W2098646537 countsByYear W20986465372013 @default.
- W2098646537 countsByYear W20986465372017 @default.
- W2098646537 countsByYear W20986465372019 @default.
- W2098646537 countsByYear W20986465372020 @default.
- W2098646537 crossrefType "journal-article" @default.
- W2098646537 hasAuthorship W2098646537A5009824094 @default.
- W2098646537 hasAuthorship W2098646537A5015030223 @default.
- W2098646537 hasAuthorship W2098646537A5018182534 @default.
- W2098646537 hasAuthorship W2098646537A5018866207 @default.
- W2098646537 hasAuthorship W2098646537A5025748633 @default.
- W2098646537 hasAuthorship W2098646537A5026608718 @default.
- W2098646537 hasAuthorship W2098646537A5036374138 @default.
- W2098646537 hasAuthorship W2098646537A5072809750 @default.
- W2098646537 hasAuthorship W2098646537A5077483738 @default.
- W2098646537 hasAuthorship W2098646537A5078718906 @default.
- W2098646537 hasAuthorship W2098646537A5079097090 @default.
- W2098646537 hasAuthorship W2098646537A5086892094 @default.
- W2098646537 hasAuthorship W2098646537A5089532607 @default.
- W2098646537 hasBestOaLocation W20986465372 @default.
- W2098646537 hasConcept C104292427 @default.
- W2098646537 hasConcept C104317684 @default.
- W2098646537 hasConcept C105580179 @default.
- W2098646537 hasConcept C150194340 @default.
- W2098646537 hasConcept C153911025 @default.
- W2098646537 hasConcept C181199279 @default.
- W2098646537 hasConcept C194583182 @default.
- W2098646537 hasConcept C25602115 @default.
- W2098646537 hasConcept C27740335 @default.
- W2098646537 hasConcept C2779535977 @default.
- W2098646537 hasConcept C2781307694 @default.
- W2098646537 hasConcept C54355233 @default.