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• W2098654083 abstract "Mechanism of action and clinical activity of tasquinimod in castrate-resistant prostate cancer Neha Gupta, Omar Al Ustwani, Li Shen, Roberto Pili Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA Abstract: Castrate-resistant prostate cancer (CRPC) is a disease where survival is poor and treatment is challenging. Over the past 3 years, significant advances in the field have been made with US Food and Drug Administration approval of new drugs for patients with CRPC. However, despite the presence of new approved drugs such as enzalutamide, abiraterone, sipuleucel-T, cabazitaxel, and alpharadin, there is still an unmet need for novel agents with different mechanisms of action to target CRPC. Based on earlier studies demonstrating therapeutic potential of a quinoline-3-carboxamide agent roquinimex as an anticancer drug, efforts were directed to identify other useful members in this class. Tasquinimod is a second-generation quinoline-3-carboxamide agent that is currently in final stages of clinical development as a treatment for CRPC. The preclinical studies of tasquinimod have formed the basis for its success as an antiangiogenic and immunomodulatory agent in this disease. Tasquinimod is an orally available agent that has shown efficacy and favorable safety profile as deduced by the results of Phase I and II clinical trials of this drug in prostate cancer. The place of tasquinimod in the treatment of CRPC patients is currently under examination in an ongoing Phase III clinical trial. In this review, we will discuss tasquinimod, starting from its discovery and current knowledge on potential mechanisms of action to its clinical potential in CRPC. Keywords: ABR-215050, quinoline-3-carboxamide, prostate adenocarcinoma, castration resistant" @default.
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• W2098654083 date "2014-02-01" @default.
• W2098654083 modified "2023-09-25" @default.
• W2098654083 title "Mechanism of action and clinical activity of tasquinimod in castrate-resistant prostate cancer" @default.
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• W2098654083 doi "https://doi.org/10.2147/ott.s53524" @default.
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