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- W2098667812 abstract "† The effect of intralesional α2-interferon (IFN) on actinic keratoses was examined in this two-part study. In phase I, 11 of 12 lesions cleared following nine injections of IFN (5 × 10<sup>5</sup>IU per dose) compared with none of 12 keratoses injected with placebo. Smaller doses of IFN (1 × 10<sup>5</sup>IU and 1 × 10<sup>4</sup>IU per injection) produced clearing of 42% and 58% of lesions, respectively. The second phase, which was designed to investigate the optimum schedule for treatment with IFN, showed that a minimum of six injections of IFN (5 × 10<sup>5</sup>IU per injection) was necessary to clear 14 of 15 actinic keratoses. Although this mode of delivery is not practical for clinical use, intralesional α2-IFN demonstrates biologic activity against actinic keratoses. (<i>Arch Dermatol</i>1986;122:779-782)" @default.
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- W2098667812 date "1986-07-01" @default.
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- W2098667812 title "Effect of Intralesional a2-Interferon on Actinic Keratoses" @default.
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- W2098667812 doi "https://doi.org/10.1001/archderm.1986.01660190057016" @default.
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