FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098672022> ?p ?o ?g. }

• W2098672022 abstract "Agents that form methylation adducts in DNA are highly mutagenic and carcinogenic, and organisms have evolved specialized cellular pathways devoted to their repair, including DNA alkyltransferases. These are proteins conserved in eucarya, bacteria and archaea, acting by a unique reaction mechanism, which leads to direct repair of DNA alkylation damage and irreversible protein alkylation. The alkylated form of DNA alkyltransferases is inactive, and in eukaryotes, it is rapidly directed to degradation. We report here in vitro and in vivo studies on the DNA alkyltransferase from the thermophilic archaeon Sulfolobus solfataricus (SsOGT). The development of a novel, simple, and sensitive fluorescence-based assay allowed a careful characterization of the SsOGT biochemical and DNA binding activities. In addition, transcriptional and post-translational regulation of SsOGT by DNA damage was studied. We show that although the gene transcription is induced by alkylating agent treatment, the protein is degraded in vivo by an alkylation-dependent mechanism. These experiments suggest a striking conservation, from archaea to humans, of this important pathway safeguarding genome stability." @default.
• W2098672022 created "2016-06-24" @default.
• W2098672022 creator A5017132282 @default.
• W2098672022 creator A5021870316 @default.
• W2098672022 creator A5045705816 @default.
• W2098672022 creator A5060740762 @default.
• W2098672022 creator A5061989033 @default.
• W2098672022 creator A5075869335 @default.
• W2098672022 creator A5086318288 @default.
• W2098672022 date "2015-01-01" @default.
• W2098672022 modified "2023-10-17" @default.
• W2098672022 title "Activity and regulation of archaeal DNA alkyltransferase. CONSERVED PROTEIN INVOLVED IN REPAIR OF DNA ALKYLATION DAMAGE." @default.
• W2098672022 cites W1550292471 @default.
• W2098672022 cites W1877934626 @default.
• W2098672022 cites W1964082387 @default.
• W2098672022 cites W1987038511 @default.
• W2098672022 cites W1988822278 @default.
• W2098672022 cites W1993466974 @default.
• W2098672022 cites W1993931802 @default.
• W2098672022 cites W1996338823 @default.
• W2098672022 cites W2008466187 @default.
• W2098672022 cites W2016036293 @default.
• W2098672022 cites W2033386962 @default.
• W2098672022 cites W2038828398 @default.
• W2098672022 cites W2049163206 @default.
• W2098672022 cites W2049862836 @default.
• W2098672022 cites W2050071709 @default.
• W2098672022 cites W2056771672 @default.
• W2098672022 cites W2057141116 @default.
• W2098672022 cites W2068373996 @default.
• W2098672022 cites W2074977677 @default.
• W2098672022 cites W2085855741 @default.
• W2098672022 cites W2094763329 @default.
• W2098672022 cites W2110612352 @default.
• W2098672022 cites W2111689950 @default.
• W2098672022 cites W2114148850 @default.
• W2098672022 cites W2121560055 @default.
• W2098672022 cites W2124389753 @default.
• W2098672022 cites W2140784559 @default.
• W2098672022 cites W2143983454 @default.
• W2098672022 cites W2145498720 @default.
• W2098672022 cites W2167447947 @default.
• W2098672022 cites W2170427174 @default.
• W2098672022 doi "https://doi.org/10.1074/jbc.a111.308320" @default.
• W2098672022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4294512" @default.
• W2098672022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22167184" @default.
• W2098672022 hasPublicationYear "2015" @default.
• W2098672022 type Work @default.
• W2098672022 sameAs 2098672022 @default.
• W2098672022 citedByCount "13" @default.
• W2098672022 countsByYear W20986720222015 @default.
• W2098672022 countsByYear W20986720222016 @default.
• W2098672022 countsByYear W20986720222017 @default.
• W2098672022 countsByYear W20986720222019 @default.
• W2098672022 countsByYear W20986720222022 @default.
• W2098672022 countsByYear W20986720222023 @default.
• W2098672022 crossrefType "journal-article" @default.
• W2098672022 hasAuthorship W2098672022A5017132282 @default.
• W2098672022 hasAuthorship W2098672022A5021870316 @default.
• W2098672022 hasAuthorship W2098672022A5045705816 @default.
• W2098672022 hasAuthorship W2098672022A5060740762 @default.
• W2098672022 hasAuthorship W2098672022A5061989033 @default.
• W2098672022 hasAuthorship W2098672022A5075869335 @default.
• W2098672022 hasAuthorship W2098672022A5086318288 @default.
• W2098672022 hasBestOaLocation W20986720221 @default.
• W2098672022 hasConcept C104317684 @default.
• W2098672022 hasConcept C134935766 @default.
• W2098672022 hasConcept C143425029 @default.
• W2098672022 hasConcept C2780631447 @default.
• W2098672022 hasConcept C550995028 @default.
• W2098672022 hasConcept C552990157 @default.
• W2098672022 hasConcept C55493867 @default.
• W2098672022 hasConcept C86803240 @default.
• W2098672022 hasConcept C95444343 @default.
• W2098672022 hasConceptScore W2098672022C104317684 @default.
• W2098672022 hasConceptScore W2098672022C134935766 @default.
• W2098672022 hasConceptScore W2098672022C143425029 @default.
• W2098672022 hasConceptScore W2098672022C2780631447 @default.
• W2098672022 hasConceptScore W2098672022C550995028 @default.
• W2098672022 hasConceptScore W2098672022C552990157 @default.
• W2098672022 hasConceptScore W2098672022C55493867 @default.
• W2098672022 hasConceptScore W2098672022C86803240 @default.
• W2098672022 hasConceptScore W2098672022C95444343 @default.
• W2098672022 hasLocation W20986720221 @default.
• W2098672022 hasLocation W20986720222 @default.
• W2098672022 hasLocation W20986720223 @default.
• W2098672022 hasLocation W20986720224 @default.
• W2098672022 hasLocation W20986720225 @default.
• W2098672022 hasOpenAccess W2098672022 @default.
• W2098672022 hasPrimaryLocation W20986720221 @default.
• W2098672022 hasRelatedWork W1859592247 @default.
• W2098672022 hasRelatedWork W1948660767 @default.
• W2098672022 hasRelatedWork W1979392838 @default.
• W2098672022 hasRelatedWork W1982720579 @default.
• W2098672022 hasRelatedWork W1996338823 @default.
• W2098672022 hasRelatedWork W1999549596 @default.
• W2098672022 hasRelatedWork W2008466187 @default.
• W2098672022 hasRelatedWork W2016036293 @default.
• W2098672022 hasRelatedWork W2025515800 @default.
• W2098672022 hasRelatedWork W2049163206 @default.

• next