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• W2098687851 abstract "The dynamic modification of nuclear and cytoplasmic proteins with O-linked beta-N-acetylglucosamine (O-GlcNAc) by the O-linked N-acetylglucosaminyltransferase (OGT) is a regulatory post-translational modification that is responsive to various stimuli. Here, we demonstrate that OGT is a central factor for T- and B-lymphocytes activation. SiRNA-mediated knockdown of OGT in T cells leads to an impaired activation of the transcription factors NFAT and NFkappaB. This results in a reduction of IL-2 production consistent with prevention of T-cell activation. OGT is also required for the early activation of B cells mediated by stimulation of the B-cell receptor. Mechanistically, we demonstrate that NFkappaB as well as NFAT are glycosylated with O-GlcNAc after direct binding to OGT. Moreover, kinetic experiments show that O-GlcNAc modification prominently increased shortly after activation of lymphoid cells and it might be required for nuclear translocation of the transcription factors NFkappaB and NFAT." @default.
• W2098687851 created "2016-06-24" @default.
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• W2098687851 date "2007-09-20" @default.
• W2098687851 modified "2023-10-08" @default.
• W2098687851 title "Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation" @default.
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• W2098687851 doi "https://doi.org/10.1038/sj.emboj.7601845" @default.
• W2098687851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2034663" @default.
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