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- W2098689981 abstract "Over the span of 40 y and with the participation of over 60 students and postdoctoral colleagues, my laboratory has been able to elucidate numerous aspects of cofactor metabolism and function. Findings have been on the absorption, transport, utilization and excretion of vitamin B-6, riboflavin, biotin, lipoate and ascorbate. Specificity studies on those trace but essential enzymes that catalyze conversion of such vitamins as B-6 and riboflavin to their functional coenzymes led to our development of biochemically specific absorbents that prototypically exemplified what later was called affinity chromatography. Characterization of the purified kinases for B-6 and riboflavin revealed preference for Zn2+ with the eucaryotic enzymes and delimited effects of inhibitors that relate to drug action. Flavin adenine dinucleotide synthetase, separable from flavokinase in mammals, prefers Mg2+. Specifics for binding and function of flavocoenzymes were delineated for several flavoproteins. The flavin mononucleotide-dependent oxidase that converts the 5'-phosphates of pyridoxine and of pyridoxamine to pyridoxal phosphate is a connection between riboflavin and B-6 that we characterized in mechanistic detail and found to be the primary control point for conversion of B-6 to its coenzyme. Sequencing and cloning of a side-chain oxidase for riboflavin was achieved. Isolation and identification of metabolites of biotin and of lipoic acid, first from bacteria obtained by enrichment culture and then from mammals, provided seminal information on catabolic pathways involved, as have our other studies with flavin catabolites isolated from milk and urine." @default.
- W2098689981 created "2016-06-24" @default.
- W2098689981 creator A5064778502 @default.
- W2098689981 date "2000-02-01" @default.
- W2098689981 modified "2023-09-30" @default.
- W2098689981 title "A Trail of Research on Cofactors: An Odyssey with Friends" @default.
- W2098689981 cites W107041052 @default.
- W2098689981 cites W126400802 @default.
- W2098689981 cites W1490035133 @default.
- W2098689981 cites W1503158388 @default.
- W2098689981 cites W1505108478 @default.
- W2098689981 cites W1515444058 @default.
- W2098689981 cites W1517916753 @default.
- W2098689981 cites W152208539 @default.
- W2098689981 cites W1529852090 @default.
- W2098689981 cites W1535458425 @default.
- W2098689981 cites W1536030564 @default.
- W2098689981 cites W1536806630 @default.
- W2098689981 cites W1540119080 @default.
- W2098689981 cites W1545164422 @default.
- W2098689981 cites W1545204869 @default.
- W2098689981 cites W1548953087 @default.
- W2098689981 cites W1552024924 @default.
- W2098689981 cites W1571464228 @default.
- W2098689981 cites W1585675907 @default.
- W2098689981 cites W1586086718 @default.
- W2098689981 cites W1588820864 @default.
- W2098689981 cites W1589296960 @default.
- W2098689981 cites W1589580009 @default.
- W2098689981 cites W1600342641 @default.
- W2098689981 cites W1608369767 @default.
- W2098689981 cites W1608761121 @default.
- W2098689981 cites W1614841340 @default.
- W2098689981 cites W1818763050 @default.
- W2098689981 cites W183877184 @default.
- W2098689981 cites W1882723571 @default.
- W2098689981 cites W1911753375 @default.
- W2098689981 cites W1948662166 @default.
- W2098689981 cites W1960882787 @default.
- W2098689981 cites W1962644427 @default.
- W2098689981 cites W1968735891 @default.
- W2098689981 cites W1969296807 @default.
- W2098689981 cites W1969871745 @default.
- W2098689981 cites W1970518439 @default.
- W2098689981 cites W1970779988 @default.
- W2098689981 cites W1973794949 @default.
- W2098689981 cites W1974017927 @default.
- W2098689981 cites W1975749571 @default.
- W2098689981 cites W1975789980 @default.
- W2098689981 cites W1976758946 @default.
- W2098689981 cites W1977121598 @default.
- W2098689981 cites W1978652852 @default.
- W2098689981 cites W1979206164 @default.
- W2098689981 cites W1982581544 @default.
- W2098689981 cites W1983693004 @default.
- W2098689981 cites W1985314717 @default.
- W2098689981 cites W1987738253 @default.
- W2098689981 cites W1987934433 @default.
- W2098689981 cites W1988218799 @default.
- W2098689981 cites W1988463430 @default.
- W2098689981 cites W1990959384 @default.
- W2098689981 cites W1991915190 @default.
- W2098689981 cites W1995411991 @default.
- W2098689981 cites W2000094205 @default.
- W2098689981 cites W2001975249 @default.
- W2098689981 cites W2005461853 @default.
- W2098689981 cites W2007465693 @default.
- W2098689981 cites W2008330957 @default.
- W2098689981 cites W2009042006 @default.
- W2098689981 cites W2012145688 @default.
- W2098689981 cites W2014056253 @default.
- W2098689981 cites W2014415102 @default.
- W2098689981 cites W2014512141 @default.
- W2098689981 cites W2015634590 @default.
- W2098689981 cites W2016206074 @default.
- W2098689981 cites W2016207861 @default.
- W2098689981 cites W2016432084 @default.
- W2098689981 cites W2017792613 @default.
- W2098689981 cites W2017896520 @default.
- W2098689981 cites W2019774123 @default.
- W2098689981 cites W2020224287 @default.
- W2098689981 cites W2022056270 @default.
- W2098689981 cites W2023070987 @default.
- W2098689981 cites W2026248208 @default.
- W2098689981 cites W2026442894 @default.
- W2098689981 cites W2027077380 @default.
- W2098689981 cites W2028123737 @default.
- W2098689981 cites W2033492383 @default.
- W2098689981 cites W2035896382 @default.
- W2098689981 cites W2041770676 @default.
- W2098689981 cites W2043376602 @default.
- W2098689981 cites W2044877200 @default.
- W2098689981 cites W2047107006 @default.
- W2098689981 cites W2048585738 @default.
- W2098689981 cites W2049127757 @default.
- W2098689981 cites W2050672744 @default.
- W2098689981 cites W2051369417 @default.
- W2098689981 cites W2052258838 @default.