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- W2098705412 abstract "<h3>Objective</h3> To investigate the effect of Vitamin C on the cardiomyocytes differentiation of mouse induced pluripotent stem cells (miPS). <h3>Methods</h3> Embryoid bodies (EBs) formed from miPS were induced by differentiation medium containing various concentration of Vitamin C. <h3>Results</h3> The best concentration of Vitamin C to promote the cardiac differentiation of miPS is 10<sup>−4</sup> mol/l, beating area was found in 57.00%±3.20% of EBs. There was a significant difference compared with the control group 5.13%±0.55% (p<0.01). Special cardiac proteins α-actin and cTnT were detected. <h3>Conclusion</h3> Vitamin C could redound differentiation of miPS to cardiomyocytes, and it is a safe and a highly efficient method in vitro." @default.
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- W2098705412 date "2011-10-01" @default.
- W2098705412 modified "2023-09-26" @default.
- W2098705412 title "Vitamin C promotes differentiation of mouse induced pluripotent stem cells into cardiomyocyte in vitro" @default.
- W2098705412 doi "https://doi.org/10.1136/heartjnl-2011-300867.23" @default.
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