FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098706371> ?p ?o ?g. }

• W2098706371 endingPage "333" @default.
• W2098706371 startingPage "328" @default.
• W2098706371 abstract "Objective Preeclampsia is associated with an imbalance between oxidants and antioxidants, resulting in reduced effects of the endothelium-derived, relaxing-factor nitric oxide (NO). Antioxidants, like N-acetylcysteine (NAC), remove reactive oxygen species, resulting in an improvement of endothelial function. We aimed to investigate the effect of NAC on the NO-pathway in the human fetoplacental circulation in preeclampsia and control pregnancies. Study design The NO-pathway was investigated by use of the NO-synthase inhibitor L-NAME in an ex vivo cotyledon perfusion model. Results At baseline, fetoplacental arterial pressure was comparable in preeclamptic pregnancies (n = 8) and control pregnancies (n = 8), and increased dose-dependently after L-NAME. The maximal L-NAME–induced rise in fetoplacental arterial pressure was attenuated in preeclamptic versus control pregnancies (20.8 ± 2.0 mm Hg vs 36.7 ± 3.5 mm Hg, P<.05). Addition of NAC increased the L-NAME–induced rise in fetoplacental arterial pressure to 36.4 ± 3.4 mm Hg in preeclampsia pregnancies (P<.05) and to 49.2 ± 2.6 mm Hg in control pregnancies (P<.05). Conclusion Preeclampsia is associated with a dysfunction of the NO-pathway. N-acetylcysteine increases NO-mediated effects in the fetoplacental circulation in preeclamptic placentas as well as in healthy control placentas." @default.
• W2098706371 created "2016-06-24" @default.
• W2098706371 creator A5003922058 @default.
• W2098706371 creator A5025993114 @default.
• W2098706371 creator A5027784857 @default.
• W2098706371 creator A5038692766 @default.
• W2098706371 creator A5048880494 @default.
• W2098706371 creator A5075145005 @default.
• W2098706371 date "2004-07-01" @default.
• W2098706371 modified "2023-10-16" @default.
• W2098706371 title "N-acetylcysteine restores nitric oxide–mediated effects in the fetoplacental circulation of preeclamptic patients" @default.
• W2098706371 cites W1857502105 @default.
• W2098706371 cites W1965355582 @default.
• W2098706371 cites W1973274253 @default.
• W2098706371 cites W1979510658 @default.
• W2098706371 cites W1982458536 @default.
• W2098706371 cites W1985166831 @default.
• W2098706371 cites W1993225499 @default.
• W2098706371 cites W1998581845 @default.
• W2098706371 cites W2000197014 @default.
• W2098706371 cites W2018382369 @default.
• W2098706371 cites W2020974295 @default.
• W2098706371 cites W2023626180 @default.
• W2098706371 cites W2030733295 @default.
• W2098706371 cites W2065456443 @default.
• W2098706371 cites W2082838271 @default.
• W2098706371 cites W2083143372 @default.
• W2098706371 cites W2094928693 @default.
• W2098706371 cites W2122272939 @default.
• W2098706371 cites W2132019871 @default.
• W2098706371 cites W2143810326 @default.
• W2098706371 cites W2172069911 @default.
• W2098706371 cites W4241749188 @default.
• W2098706371 doi "https://doi.org/10.1016/j.ajog.2003.12.033" @default.
• W2098706371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15295387" @default.
• W2098706371 hasPublicationYear "2004" @default.
• W2098706371 type Work @default.
• W2098706371 sameAs 2098706371 @default.
• W2098706371 citedByCount "29" @default.
• W2098706371 countsByYear W20987063712012 @default.
• W2098706371 countsByYear W20987063712014 @default.
• W2098706371 countsByYear W20987063712015 @default.
• W2098706371 countsByYear W20987063712016 @default.
• W2098706371 countsByYear W20987063712018 @default.
• W2098706371 countsByYear W20987063712019 @default.
• W2098706371 countsByYear W20987063712020 @default.
• W2098706371 countsByYear W20987063712021 @default.
• W2098706371 countsByYear W20987063712022 @default.
• W2098706371 crossrefType "journal-article" @default.
• W2098706371 hasAuthorship W2098706371A5003922058 @default.
• W2098706371 hasAuthorship W2098706371A5025993114 @default.
• W2098706371 hasAuthorship W2098706371A5027784857 @default.
• W2098706371 hasAuthorship W2098706371A5038692766 @default.
• W2098706371 hasAuthorship W2098706371A5048880494 @default.
• W2098706371 hasAuthorship W2098706371A5075145005 @default.
• W2098706371 hasConcept C126322002 @default.
• W2098706371 hasConcept C134018914 @default.
• W2098706371 hasConcept C146957229 @default.
• W2098706371 hasConcept C172680121 @default.
• W2098706371 hasConcept C2776953305 @default.
• W2098706371 hasConcept C2776992346 @default.
• W2098706371 hasConcept C2777218350 @default.
• W2098706371 hasConcept C2777847592 @default.
• W2098706371 hasConcept C2778004101 @default.
• W2098706371 hasConcept C2779234561 @default.
• W2098706371 hasConcept C2780972559 @default.
• W2098706371 hasConcept C519581460 @default.
• W2098706371 hasConcept C54355233 @default.
• W2098706371 hasConcept C55493867 @default.
• W2098706371 hasConcept C71924100 @default.
• W2098706371 hasConcept C84393581 @default.
• W2098706371 hasConcept C86803240 @default.
• W2098706371 hasConceptScore W2098706371C126322002 @default.
• W2098706371 hasConceptScore W2098706371C134018914 @default.
• W2098706371 hasConceptScore W2098706371C146957229 @default.
• W2098706371 hasConceptScore W2098706371C172680121 @default.
• W2098706371 hasConceptScore W2098706371C2776953305 @default.
• W2098706371 hasConceptScore W2098706371C2776992346 @default.
• W2098706371 hasConceptScore W2098706371C2777218350 @default.
• W2098706371 hasConceptScore W2098706371C2777847592 @default.
• W2098706371 hasConceptScore W2098706371C2778004101 @default.
• W2098706371 hasConceptScore W2098706371C2779234561 @default.
• W2098706371 hasConceptScore W2098706371C2780972559 @default.
• W2098706371 hasConceptScore W2098706371C519581460 @default.
• W2098706371 hasConceptScore W2098706371C54355233 @default.
• W2098706371 hasConceptScore W2098706371C55493867 @default.
• W2098706371 hasConceptScore W2098706371C71924100 @default.
• W2098706371 hasConceptScore W2098706371C84393581 @default.
• W2098706371 hasConceptScore W2098706371C86803240 @default.
• W2098706371 hasIssue "1" @default.
• W2098706371 hasLocation W20987063711 @default.
• W2098706371 hasLocation W20987063712 @default.
• W2098706371 hasOpenAccess W2098706371 @default.
• W2098706371 hasPrimaryLocation W20987063711 @default.
• W2098706371 hasRelatedWork W1607531870 @default.
• W2098706371 hasRelatedWork W2022809694 @default.
• W2098706371 hasRelatedWork W2025791617 @default.
• W2098706371 hasRelatedWork W2028770962 @default.

• next