Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098708412> ?p ?o ?g. }
- W2098708412 endingPage "1216" @default.
- W2098708412 startingPage "1203" @default.
- W2098708412 abstract "Interspersed repeats have emerged as a valuable tool for studying neutral patterns of molecular evolution. Here we analyze variation in the rate and pattern of nucleotide substitution across all autosomes in the chicken genome by comparing the present-day CR1 repeat sequences with their ancestral copies and reconstructing nucleotide substitutions with a maximum likelihood model. The results shed light on the origin and evolution of large-scale heterogeneity in GC content found in the genomes of birds and mammals—the isochore structure. In contrast to mammals, where GC content is becoming homogenized, heterogeneity in GC content is being reinforced in the chicken genome. This is also supported by patterns of substitution inferred from alignments of introns in chicken, turkey, and quail. Analysis of individual substitution frequencies is consistent with the biased gene conversion (BGC) model of isochore evolution, and it is likely that patterns of evolution in the chicken genome closely resemble those in the ancestral amniote genome, when it is inferred that isochores originated. Microchromosomes and distal regions of macrochromosomes are found to have elevated substitution rates and a more GC-biased pattern of nucleotide substitution. This can largely be accounted for by a strong correlation between GC content and the rate and pattern of substitution. The results suggest that an interaction between increased mutability at CpG motifs and fixation biases due to BGC could explain increased levels of divergence in GC-rich regions." @default.
- W2098708412 created "2016-06-24" @default.
- W2098708412 creator A5014063704 @default.
- W2098708412 creator A5073922372 @default.
- W2098708412 creator A5087265755 @default.
- W2098708412 date "2006-03-21" @default.
- W2098708412 modified "2023-09-23" @default.
- W2098708412 title "Strong Regional Biases in Nucleotide Substitution in the Chicken Genome" @default.
- W2098708412 cites W1517914487 @default.
- W2098708412 cites W1963602582 @default.
- W2098708412 cites W1964885249 @default.
- W2098708412 cites W1965240564 @default.
- W2098708412 cites W1965307886 @default.
- W2098708412 cites W1966585515 @default.
- W2098708412 cites W1966947301 @default.
- W2098708412 cites W1969461149 @default.
- W2098708412 cites W1975001280 @default.
- W2098708412 cites W1978876379 @default.
- W2098708412 cites W1979975741 @default.
- W2098708412 cites W1982363088 @default.
- W2098708412 cites W1982603712 @default.
- W2098708412 cites W1982906065 @default.
- W2098708412 cites W1989563297 @default.
- W2098708412 cites W1992834799 @default.
- W2098708412 cites W2001247487 @default.
- W2098708412 cites W2006664581 @default.
- W2098708412 cites W2006746194 @default.
- W2098708412 cites W2014078041 @default.
- W2098708412 cites W2019659839 @default.
- W2098708412 cites W2034078054 @default.
- W2098708412 cites W2034353459 @default.
- W2098708412 cites W2035313111 @default.
- W2098708412 cites W2038359695 @default.
- W2098708412 cites W2041747211 @default.
- W2098708412 cites W2041922986 @default.
- W2098708412 cites W2042687932 @default.
- W2098708412 cites W2043592686 @default.
- W2098708412 cites W2050295822 @default.
- W2098708412 cites W2052058909 @default.
- W2098708412 cites W2064438511 @default.
- W2098708412 cites W2064912476 @default.
- W2098708412 cites W2067007270 @default.
- W2098708412 cites W2069183470 @default.
- W2098708412 cites W2069639379 @default.
- W2098708412 cites W2076634000 @default.
- W2098708412 cites W2077768442 @default.
- W2098708412 cites W2081229967 @default.
- W2098708412 cites W2092464006 @default.
- W2098708412 cites W2096479647 @default.
- W2098708412 cites W2099701655 @default.
- W2098708412 cites W2101768075 @default.
- W2098708412 cites W2102999073 @default.
- W2098708412 cites W2104743461 @default.
- W2098708412 cites W2106882534 @default.
- W2098708412 cites W2107940434 @default.
- W2098708412 cites W2109899970 @default.
- W2098708412 cites W2111534865 @default.
- W2098708412 cites W2115672772 @default.
- W2098708412 cites W2117476893 @default.
- W2098708412 cites W2125036863 @default.
- W2098708412 cites W2125383928 @default.
- W2098708412 cites W2125685565 @default.
- W2098708412 cites W2127150942 @default.
- W2098708412 cites W2131669390 @default.
- W2098708412 cites W2133178637 @default.
- W2098708412 cites W2134535493 @default.
- W2098708412 cites W2138790911 @default.
- W2098708412 cites W2140596904 @default.
- W2098708412 cites W2143467725 @default.
- W2098708412 cites W2144943869 @default.
- W2098708412 cites W2151899848 @default.
- W2098708412 cites W2152453825 @default.
- W2098708412 cites W2155964482 @default.
- W2098708412 cites W2164311122 @default.
- W2098708412 cites W2168909179 @default.
- W2098708412 cites W2171220883 @default.
- W2098708412 cites W2549117626 @default.
- W2098708412 cites W2793222991 @default.
- W2098708412 cites W4243739545 @default.
- W2098708412 cites W4292239814 @default.
- W2098708412 cites W91245336 @default.
- W2098708412 doi "https://doi.org/10.1093/molbev/msk008" @default.
- W2098708412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16551647" @default.
- W2098708412 hasPublicationYear "2006" @default.
- W2098708412 type Work @default.
- W2098708412 sameAs 2098708412 @default.
- W2098708412 citedByCount "98" @default.
- W2098708412 countsByYear W20987084122012 @default.
- W2098708412 countsByYear W20987084122013 @default.
- W2098708412 countsByYear W20987084122014 @default.
- W2098708412 countsByYear W20987084122015 @default.
- W2098708412 countsByYear W20987084122016 @default.
- W2098708412 countsByYear W20987084122017 @default.
- W2098708412 countsByYear W20987084122018 @default.
- W2098708412 countsByYear W20987084122019 @default.
- W2098708412 countsByYear W20987084122020 @default.
- W2098708412 countsByYear W20987084122021 @default.
- W2098708412 countsByYear W20987084122022 @default.