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• W2098717020 endingPage "755" @default.
• W2098717020 startingPage "746" @default.
• W2098717020 abstract "Embryonic stem (ES) cells have a unique regulatory circuitry, largely controlled by the transcription factors Oct4, Sox2, and Nanog, which generates a gene expression program necessary for pluripotency and self-renewal. How external signals connect to this regulatory circuitry to influence ES cell fate is not known. We report here that a terminal component of the canonical Wnt pathway in ES cells, the transcription factor T-cell factor-3 (Tcf3), co-occupies promoters throughout the genome in association with the pluripotency regulators Oct4 and Nanog. Thus, Tcf3 is an integral component of the core regulatory circuitry of ES cells, which includes an autoregulatory loop involving the pluripotency regulators. Both Tcf3 depletion and Wnt pathway activation cause increased expression of Oct4, Nanog, and other pluripotency factors and produce ES cells that are refractory to differentiation. Our results suggest that the Wnt pathway, through Tcf3, brings developmental signals directly to the core regulatory circuitry of ES cells to influence the balance between pluripotency and differentiation." @default.
• W2098717020 created "2016-06-24" @default.
• W2098717020 creator A5018576178 @default.
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• W2098717020 creator A5035504462 @default.
• W2098717020 creator A5057814473 @default.
• W2098717020 date "2008-03-15" @default.
• W2098717020 modified "2023-10-13" @default.
• W2098717020 title "Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells" @default.
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• W2098717020 doi "https://doi.org/10.1101/gad.1642408" @default.
• W2098717020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2275428" @default.
• W2098717020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18347094" @default.
• W2098717020 hasPublicationYear "2008" @default.
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