FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098739109> ?p ?o ?g. }

• W2098739109 endingPage "12188" @default.
• W2098739109 startingPage "12179" @default.
• W2098739109 abstract "CD8(+) cytotoxic T lymphocytes (CTL) are strong mediators of human immunodeficiency virus type 1 (HIV-1) control, yet HIV-1 frequently mutates to escape CTL recognition. In an analysis of sequences in the Los Alamos HIV-1 database, we show that emerging CTL escape mutations were more often present at lower frequencies than the amino acid(s) that they replaced. Furthermore, epitopes that underwent escape contained amino acid sites of high variability, whereas epitopes persisting at high frequencies lacked highly variable sites. We therefore infer that escape mutations are likely to be associated with weak functional constraints on the viral protein. This was supported by an extensive analysis of one subject for whom all escape mutations within defined CTL epitopes were studied and by an analysis of all reported escape mutations of defined CTL epitopes in the HIV Immunology Database. In one of these defined epitopes, escape mutations involving the substitution of amino acids with lower database frequencies occurred, and the epitope soon reverted back to the sensitive form. We further show that this escape mutation substantially diminished viral fitness in in vitro competition assays. Coincident with the reversion in vivo, we observed the fixation of a mutation 3 amino acids C terminal to the epitope, coincident with the ablation of the corresponding CTL response. The C-terminal mutation did not restore replication fitness reduced by the escape mutation in the epitope and by itself had little effect on replication fitness. Therefore, this C-terminal mutation presumably impaired the processing and presentation of the epitope. Finally, for one persistent epitope, CTL cross-reactivity to a mutant form may have suppressed the mutant to undetected levels, whereas for two other persistent epitopes, each of two mutants showed poor cross-reactivity and appeared in the subject at later time points. Thus, a viral dynamic exists between the advantage of immune escape, peptide cross-reactivity, and the disadvantage of lost replication fitness, with the balance playing an important role in determining whether a CTL epitope will persist or decline during infection." @default.
• W2098739109 created "2016-06-24" @default.
• W2098739109 creator A5003222426 @default.
• W2098739109 creator A5003924565 @default.
• W2098739109 creator A5008659449 @default.
• W2098739109 creator A5016248534 @default.
• W2098739109 creator A5018875016 @default.
• W2098739109 creator A5028336562 @default.
• W2098739109 creator A5052566599 @default.
• W2098739109 creator A5070829421 @default.
• W2098739109 creator A5074401742 @default.
• W2098739109 creator A5079955467 @default.
• W2098739109 creator A5084520588 @default.
• W2098739109 date "2007-11-15" @default.
• W2098739109 modified "2023-10-18" @default.
• W2098739109 title "Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape" @default.
• W2098739109 cites W1479760379 @default.
• W2098739109 cites W1565230971 @default.
• W2098739109 cites W1572054114 @default.
• W2098739109 cites W1601810440 @default.
• W2098739109 cites W1655510925 @default.
• W2098739109 cites W1964017617 @default.
• W2098739109 cites W1964646310 @default.
• W2098739109 cites W1965681845 @default.
• W2098739109 cites W1974839791 @default.
• W2098739109 cites W1977279184 @default.
• W2098739109 cites W1986152436 @default.
• W2098739109 cites W2009102382 @default.
• W2098739109 cites W2017172508 @default.
• W2098739109 cites W2019675656 @default.
• W2098739109 cites W2030741604 @default.
• W2098739109 cites W2045551237 @default.
• W2098739109 cites W2053695022 @default.
• W2098739109 cites W2058894986 @default.
• W2098739109 cites W2060382143 @default.
• W2098739109 cites W2063485002 @default.
• W2098739109 cites W2076030521 @default.
• W2098739109 cites W2079504777 @default.
• W2098739109 cites W2081844025 @default.
• W2098739109 cites W2083255836 @default.
• W2098739109 cites W2085919513 @default.
• W2098739109 cites W2087484510 @default.
• W2098739109 cites W2092368847 @default.
• W2098739109 cites W2092434970 @default.
• W2098739109 cites W2095983332 @default.
• W2098739109 cites W2103182811 @default.
• W2098739109 cites W2105571187 @default.
• W2098739109 cites W2105813980 @default.
• W2098739109 cites W2107786521 @default.
• W2098739109 cites W2108446353 @default.
• W2098739109 cites W2108507055 @default.
• W2098739109 cites W2111391629 @default.
• W2098739109 cites W2112111895 @default.
• W2098739109 cites W2114419233 @default.
• W2098739109 cites W2118619556 @default.
• W2098739109 cites W2129114331 @default.
• W2098739109 cites W2129672006 @default.
• W2098739109 cites W2130265830 @default.
• W2098739109 cites W2133402813 @default.
• W2098739109 cites W2137085164 @default.
• W2098739109 cites W2139652666 @default.
• W2098739109 cites W2142316620 @default.
• W2098739109 cites W2146291971 @default.
• W2098739109 cites W2147134928 @default.
• W2098739109 cites W2148148789 @default.
• W2098739109 cites W2149815850 @default.
• W2098739109 cites W2151326236 @default.
• W2098739109 cites W2151651155 @default.
• W2098739109 cites W2155167450 @default.
• W2098739109 cites W2155227786 @default.
• W2098739109 cites W2157554632 @default.
• W2098739109 cites W2159652067 @default.
• W2098739109 cites W2162667658 @default.
• W2098739109 cites W2164213171 @default.
• W2098739109 cites W2166236842 @default.
• W2098739109 cites W2166374206 @default.
• W2098739109 cites W2169847792 @default.
• W2098739109 cites W2286030087 @default.
• W2098739109 cites W2336646117 @default.
• W2098739109 doi "https://doi.org/10.1128/jvi.01277-07" @default.
• W2098739109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2169017" @default.
• W2098739109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17728222" @default.
• W2098739109 hasPublicationYear "2007" @default.
• W2098739109 type Work @default.
• W2098739109 sameAs 2098739109 @default.
• W2098739109 citedByCount "81" @default.
• W2098739109 countsByYear W20987391092012 @default.
• W2098739109 countsByYear W20987391092013 @default.
• W2098739109 countsByYear W20987391092014 @default.
• W2098739109 countsByYear W20987391092015 @default.
• W2098739109 countsByYear W20987391092016 @default.
• W2098739109 countsByYear W20987391092017 @default.
• W2098739109 countsByYear W20987391092018 @default.
• W2098739109 countsByYear W20987391092019 @default.
• W2098739109 countsByYear W20987391092020 @default.
• W2098739109 countsByYear W20987391092021 @default.
• W2098739109 countsByYear W20987391092022 @default.
• W2098739109 countsByYear W20987391092023 @default.

• next