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- W2098743691 abstract "Although amphetamine (AMPH)-induced appetite suppression has been attributed to its inhibitory action on neuropeptide Y (NPY), an appetite neurotransmitter abundant in the brain, molecular mechanisms underlying this effect are not well known. This study examined the possible role of protein kinase A (PKA) and cAMP response element-binding protein (CREB) signaling in this anorectic effect, and the results showed that both PKA and CREB mRNA levels in hypothalamus were increased following AMPH treatment, which was relevant to a reduction of NPY mRNA level. To determine whether PKA or CREB was involved in the anorectic response, intracerebroventricular infusions of antisense oligonucleotide (or missense control) were performed 60 min before daily AMPH treatment in conscious rats, and results showed that either PKA or CREB knockdown could block AMPH-induced anorexia as well as restore NPY mRNA level, indicating the respective involvement of PKA and CREB signaling in the regulation of NPY gene expression. It is suggested that hypothalamic PKA and CREB signaling may involve the central regulation of AMPH-mediated feeding suppression via the modulation of NPY gene expression." @default.
- W2098743691 created "2016-06-24" @default.
- W2098743691 creator A5014260545 @default.
- W2098743691 creator A5014422191 @default.
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- W2098743691 date "2007-01-01" @default.
- W2098743691 modified "2023-09-28" @default.
- W2098743691 title "Intracerebral administration of protein kinase A or cAMP response element-binding protein antisense oligonucleotide can modulate amphetamine-mediated appetite suppression in free-moving rats" @default.
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- W2098743691 doi "https://doi.org/10.1152/ajpendo.00195.2006" @default.
- W2098743691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16896163" @default.
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