Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098752313> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2098752313 endingPage "124" @default.
- W2098752313 startingPage "115" @default.
- W2098752313 abstract "Soman (pinacolylmethylphosphonofluoridate) causes seizures and seizurerelated brain damageresulting from theirreversibleinhibition of acetylcholinesterase (AChE) in the central nervous system (CNS). The authors have examined the possibility that the loss of AChE reactivity in discrete brain regions may have importance in the development of status epilepticus caused by soman. In these studies, male Sprague-Dawley rats were given GM monosialoganglio1 side, intracerebroventricularly, via an osmotic minipump. Four days after initiation of GM1 infusions, rats were injected with 1.25 LD50 soman (83mug/kg,im). Electrocorticogram (ECoG) recordings were monitored via indwelling cortical electrodes. All rats were euthanized 27 h after soman administration. Brain tissue was sucrose-saturated, cryostat-sectioned, and processed for AChE histochemistry. A Quantimet 600 Image Analysis System and Biological Microscope were used to assess the optical density of histochemical staining for AChE in the piriform cortex, basolateral amygdaloid nucleus, and caudate putamen. All rats showed ECoG evidence of seizures within 10 min of soman administration. However, 6 of the 11 surviving rats receiving GM1 infusion did not develop status epilepticus. Statistical analysis of AChE optical densities revealed marked and significant reductions of AChE reactivity in soman-treated rats compared to controls. Soman-treated rats that did not develop status epilepticus had significant levels of residual AChE in the basolateral amygdaloid nucleus compared to other soman-challenged animals." @default.
- W2098752313 created "2016-06-24" @default.
- W2098752313 creator A5014419920 @default.
- W2098752313 creator A5074943478 @default.
- W2098752313 creator A5082177609 @default.
- W2098752313 date "1999-01-01" @default.
- W2098752313 modified "2023-09-27" @default.
- W2098752313 title "RESIDUAL ACETYLCHOLINESTERASE ACTIVITY IN THE BASAL LATERAL AMYGDALA FOLLOWING SOMAN-INDUCED STATUS EPILEPTICUS" @default.
- W2098752313 cites W131351383 @default.
- W2098752313 cites W1824128596 @default.
- W2098752313 cites W1970520842 @default.
- W2098752313 cites W1985554234 @default.
- W2098752313 cites W1986607212 @default.
- W2098752313 cites W2002175811 @default.
- W2098752313 cites W2002437982 @default.
- W2098752313 cites W2010926499 @default.
- W2098752313 cites W2046432329 @default.
- W2098752313 cites W2055749276 @default.
- W2098752313 cites W2063537428 @default.
- W2098752313 cites W2065154758 @default.
- W2098752313 cites W2079208058 @default.
- W2098752313 cites W2119125561 @default.
- W2098752313 cites W2222594107 @default.
- W2098752313 cites W2401788416 @default.
- W2098752313 cites W2418536964 @default.
- W2098752313 doi "https://doi.org/10.1080/105172399242762" @default.
- W2098752313 hasPublicationYear "1999" @default.
- W2098752313 type Work @default.
- W2098752313 sameAs 2098752313 @default.
- W2098752313 citedByCount "0" @default.
- W2098752313 crossrefType "journal-article" @default.
- W2098752313 hasAuthorship W2098752313A5014419920 @default.
- W2098752313 hasAuthorship W2098752313A5074943478 @default.
- W2098752313 hasAuthorship W2098752313A5082177609 @default.
- W2098752313 hasConcept C126322002 @default.
- W2098752313 hasConcept C134018914 @default.
- W2098752313 hasConcept C169760540 @default.
- W2098752313 hasConcept C181199279 @default.
- W2098752313 hasConcept C185592680 @default.
- W2098752313 hasConcept C2777341932 @default.
- W2098752313 hasConcept C2778186239 @default.
- W2098752313 hasConcept C2778816929 @default.
- W2098752313 hasConcept C2779059548 @default.
- W2098752313 hasConcept C2779144063 @default.
- W2098752313 hasConcept C2780266723 @default.
- W2098752313 hasConcept C2780382662 @default.
- W2098752313 hasConcept C2780451725 @default.
- W2098752313 hasConcept C2781161787 @default.
- W2098752313 hasConcept C2781423529 @default.
- W2098752313 hasConcept C42219234 @default.
- W2098752313 hasConcept C55493867 @default.
- W2098752313 hasConcept C71924100 @default.
- W2098752313 hasConcept C86803240 @default.
- W2098752313 hasConceptScore W2098752313C126322002 @default.
- W2098752313 hasConceptScore W2098752313C134018914 @default.
- W2098752313 hasConceptScore W2098752313C169760540 @default.
- W2098752313 hasConceptScore W2098752313C181199279 @default.
- W2098752313 hasConceptScore W2098752313C185592680 @default.
- W2098752313 hasConceptScore W2098752313C2777341932 @default.
- W2098752313 hasConceptScore W2098752313C2778186239 @default.
- W2098752313 hasConceptScore W2098752313C2778816929 @default.
- W2098752313 hasConceptScore W2098752313C2779059548 @default.
- W2098752313 hasConceptScore W2098752313C2779144063 @default.
- W2098752313 hasConceptScore W2098752313C2780266723 @default.
- W2098752313 hasConceptScore W2098752313C2780382662 @default.
- W2098752313 hasConceptScore W2098752313C2780451725 @default.
- W2098752313 hasConceptScore W2098752313C2781161787 @default.
- W2098752313 hasConceptScore W2098752313C2781423529 @default.
- W2098752313 hasConceptScore W2098752313C42219234 @default.
- W2098752313 hasConceptScore W2098752313C55493867 @default.
- W2098752313 hasConceptScore W2098752313C71924100 @default.
- W2098752313 hasConceptScore W2098752313C86803240 @default.
- W2098752313 hasIssue "2" @default.
- W2098752313 hasLocation W20987523131 @default.
- W2098752313 hasOpenAccess W2098752313 @default.
- W2098752313 hasPrimaryLocation W20987523131 @default.
- W2098752313 hasRelatedWork W1978801406 @default.
- W2098752313 hasRelatedWork W2009420607 @default.
- W2098752313 hasRelatedWork W2026759900 @default.
- W2098752313 hasRelatedWork W2043764137 @default.
- W2098752313 hasRelatedWork W2047615712 @default.
- W2098752313 hasRelatedWork W2053359810 @default.
- W2098752313 hasRelatedWork W2080501163 @default.
- W2098752313 hasRelatedWork W2098752313 @default.
- W2098752313 hasRelatedWork W2118070764 @default.
- W2098752313 hasRelatedWork W2361041528 @default.
- W2098752313 hasVolume "9" @default.
- W2098752313 isParatext "false" @default.
- W2098752313 isRetracted "false" @default.
- W2098752313 magId "2098752313" @default.
- W2098752313 workType "article" @default.