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- W2098777190 endingPage "119" @default.
- W2098777190 startingPage "108" @default.
- W2098777190 abstract "The discovery of RNA interference, first in plants and Caenorhabditis elegans and later in mammalian cells, led to the emergence of a transformative view in biomedical research. Knowledge of the multiple actions of non-coding RNAs has truly allowed viewing DNA, RNA and proteins in novel ways. Small interfering RNAs (siRNAs) can be used as tools to study single gene function both in vitro and in vivo and are an attractive new class of therapeutics, especially against undruggable targets for the treatment of cancer and other diseases. Despite the potential of siRNAs in cancer therapy, many challenges remain, including rapid degradation, poor cellular uptake and off-target effects. Rational design strategies, selection algorithms, chemical modifications and nanocarriers offer significant opportunities to overcome these challenges. Here, we review the development of siRNAs as therapeutic agents from early design to clinical trial, with special emphasis on the development of EphA2-targeting siRNAs for ovarian cancer treatment." @default.
- W2098777190 created "2016-06-24" @default.
- W2098777190 creator A5009234043 @default.
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- W2098777190 creator A5023542865 @default.
- W2098777190 creator A5040193650 @default.
- W2098777190 creator A5051040995 @default.
- W2098777190 date "2015-06-01" @default.
- W2098777190 modified "2023-10-17" @default.
- W2098777190 title "Preclinical and clinical development of siRNA-based therapeutics" @default.
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