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• W2098778888 abstract "Primordial follicles are formed prenatally in mammalian ovaries, and at birth they are fated to be activated to primary follicles, to be dormant, or to die. During the early stage of folliclulogenesis, the oocyte undergoes dynamic alterations in expression of numerous genes, which are regulated by transcription factors. Several germ-cell specific transcriptional regulators are critical for formation and maintenance of follicles. These transcriptional regulators include: Figla, Lhx8, Nobox, Sohlh1, and Sohlh2. A subset of these transcriptional regulators is mutated in women with ovarian insufficiency and infertility. Establishment of this oocyte pool is essential for fertility. This review focuses on these transcriptional regulators of female primordial follicles. Keywords: Primordial follicles; Transcription factors; Figla; Lhx8; Nobox; Sohlh1; Sohlh2" @default.
• W2098778888 created "2016-06-24" @default.
• W2098778888 creator A5023733387 @default.
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• W2098778888 date "2012-01-01" @default.
• W2098778888 modified "2023-09-30" @default.
• W2098778888 title "Transcription factors in the maintenance and survival of primordial follicles" @default.
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• W2098778888 doi "https://doi.org/10.5653/cerm.2012.39.4.127" @default.
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